Slowly Progressive Disease: Causes & Reasons

Possible Causes for Slowly Progressive Disease

[…] with slowly progressive selective lower extremity weakness, specifically of the hip flexors. [ncbi.nlm.nih.gov]

However, disease progression and diaphragmatic involvement both are highly variable in LOPD patients with and without ERT making it obligatory to assess and monitor respiratory [ncbi.nlm.nih.gov]

Abstract Adult-onset Pompe disease (acid maltase deficiency, glycogen storage disease type II) should be considered in the differential diagnosis in the adult patient presenting [ncbi.nlm.nih.gov]

Retinitis Pigmentosa

It should be noted that RP is a slowly progressive disease over many years and that most patients never become completely blind. [uvahealth.com]

Patients initially experience ring scotoma and night vision problems which, in most cases, slowly progress and lead to the loss of all peripheral vision. [nice.org.uk]

Patients should understand the variable, slowly progressive course of the disease that leads to bilateral, initially peripheral and later central vision loss. [institut-vision.org]

Multiple Sclerosis

A patient with RRMS may accumulate significant disability between relapses while a patient with very slowly progressive disease may remain with minimal disability. [va.gov]

progressing disease may be challenging to identify or may have been misdiagnosed with another condition. [biomarin.com]

Discussion Individuals with rapidly advancing MPS VI are diagnosed earlier than the individuals with slowly progressive disease because of the severity of symptoms, including [pediatrics.aappublications.org]

Geographic Atrophy

progressive disease. [retinatoday.com]

Geographic atrophy is a progressive disease. It will start slowly but gradually worsen. The sooner the condition is diagnosed, the sooner treatment can be started. [bolingvisioncenter.com]

Although it begins slowly, geographic atrophy is a progressive and irreversible disease that leads to central scotomas. [associatedretinaconsultants.com]

Autosomal Dominant Spastic Paraplegia Type 38

[…] paraplegia type 4; SPG4 Alt IDs: OMIM:182601, ICD10CM:G11.4, ORDO:100985 Definition: A hereditary spastic paraplegia that is characterized by slowly progressive muscle weakness [informatics.jax.org]

[…] the brain or spinal cord (e.g., tethered cord syndrome and spinal cord compression) Motor neuron disorders such as slowly progressive amyotrophic lateral sclerosis (ALS) [centogene.com]

Another DNM2 -associated disease, autosomal-dominant Centronuclear myopathy, is a slowly progressive congenital myopathy characterized by delayed motor milestones, generalized [bmcneurol.biomedcentral.com]

Myofibrillar Myopathy Type 3

Felice et al. (123) reported a family with AD adult onset slowly progressive distal myopathy without linkage to known loci. [ncbi.nlm.nih.gov]

Mutations in this gene have also been identified as a cause of LGMD1C, sporadic hyperCKemia, and rippling muscle disease (121, 122). [ncbi.nlm.nih.gov]

Nuclear Cataract

Develop an essential understanding of the principles of equine disease with this one-of-a-kind, problem-based resource! Extensively revised and updated with contributions from an international team of experts, Equine Internal Medicine, 3rd Edition reflects the latest clinical research in equine medicine and focuses on[…] [books.google.com]

Cerebrotendinous Xanthomatosis

Continuing Education Activity Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disease associated with abnormally high cholestanol levels in the blood, accumulating in the nervous system and other organ systems. The cholestanol accumulates most notably in the brain, tendons, eyes, arteries[…] [ncbi.nlm.nih.gov]

Neuronal Intranuclear Inclusion Disease

(NIID) is a slowly progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the nervous system, and in the visceral organs. [sasappa.co.jp]

Neuronal intranuclear inclusion disease (NIID) is a slowly progressive, neurodegenerative disease. [rarediseases.info.nih.gov]

Nagoya Graduate School of Medicine 2) Department of Therapeutics for Intractable Neurological Disorders, Nagoya Graduate School of Medicine Neuronal intranuclear inclusion disease [sasappa.co.jp]

Pigmented Paravenous Retinochoroidal Atrophy

Pigmented paravenous retinochoroidal atrophy is probably a slowly progressive disease, particularly in older patients. [ncbi.nlm.nih.gov]

CONCLUSION: Patients with PPRCA have a slowly progressive disease with respect to the loss of peripheral vision. [ncbi.nlm.nih.gov]

PPRCA is non-progressive or slowly progressive disease. There is no specific treatment for PPRCA. [eyewiki.org]

Spinal and Bulbar Muscular Atrophy

SBMA is a slowly progressive disease by nature. [ncbi.nlm.nih.gov]

Spinal and bulbar muscular atrophy, or Kennedy disease, is a slowly progressive X-linked neuromuscular disease caused by a trinucleotide (CAG) repeat expansion in the androgen [ncbi.nlm.nih.gov]

These findings should be thoroughly considered when designing clinical trials for slowly progressive neurodegenerative diseases such as SBMA. [ncbi.nlm.nih.gov]

Adult Krabbe Disease

It was found in homozygosity in a patient (#17) with severe early-onset disease and in heterozygosity in siblings #15 and #16, both with late-onset slowly progressing disease [ncbi.nlm.nih.gov]

However, the latter too has been shown to be beneficial in patients with very early stage Krabbe disease or a very slowly progressing type. (3, 13) Gene therapy, where scientists [news-medical.net]

It has been found that cord blood transplant stabilizes disease progression faster than bone marrow transplant. [news-medical.net]

Primary Lateral Sclerosis

[…] pri·mar·y lat·er·al scle·ro·sis considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral [medical-dictionary.thefreedictionary.com]

Prognosis Because PLS can be a slowly progressing disease, the outlook for a normal life span is good. [encyclopedia.com]

progressing degenerative brain disease characterized by weakness, spasticity, hyperreflexia, and a positive Babinski sign. [medical-dictionary.thefreedictionary.com]

Limb-Girdle Muscular Dystrophy Type 1F

Myotonic dystrophy is also known as Steinart's disease. It is a slowly progressing disease that onsets anytime from childhood through middle age. [healthcommunities.com]

progressive disease, meaning the muscle weakness slowly continues to worsen. [rarediseases.info.nih.gov]

This form is similar to Duchenne muscular dystrophy, but the disease is much milder: symptoms appear later and progress more slowly. [webmd.com]

Central Centrifugal Cicatricial Alopecia

[…] generally progresses slowly, but longstanding or severe disease can result in hair loss covering the entire crown of the scalp.[11] This is in contrast to nonscarring (non-cicatricial [ncbi.nlm.nih.gov]

Typically, a few short, brittle hairs remain within the scarred expanse.[9] Patients commonly complain of mild dysesthesia (pruritus, tenderness) in the affected area.[7,10] The disease [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy with Microcephaly and Mental Subnormality

The family reported here illustrates the relatively slowly progressive form of this disease. [onlinelibrary.wiley.com]

A wide variety of clinical manifestations are encountered in the various forms of progressive spinal muscular atrophy of childhood. [einstein.pure.elsevier.com]

SUMMARY A wide variety of clinical manifestations are encountered in the various forms of progressive spinal muscular atrophy of childhood. [onlinelibrary.wiley.com]

Cortical Senile Cataract

Advanced Search Help Advanced search lets you search selected properties of the classification. You could search all properties or a selected subset only First, you need to provide keywords in the Search Text field then check the properties that you'd like to include in the search. The system will search for the[…] [icd.who.int]

Retinitis Pigmentosa Type 20

Citation metadata Document controls Main content Abstract : La retinosis pigmentaria (RP) comprende un grupo de enfermedades degenerativas de la retina que afectan la función y el campo visual. Se caracteriza por ceguera nocturna y pérdida de campo visual periférico, y suele tener debut precoz y juvenil. Este[…] [go.gale.com]

X-Linked Juvenile Retinoschisis Type 1

Carbon Baby Syndrome

Adrenoleukodystrophy is an X-linked acquired generalized hyperpigmentary disorder, which has been described in association with a slowly progressive disease of the brain and [ijdvl.com]

TGFBI-Related Corneal Dystrophy

Most of them have an autosomal dominant pattern of inheritance, starting at the first decades of life, with a stable or slowly progressive course(2). [aboonline.org.br]

Most cases of CD have an autosomal dominant inheritance pattern, starting at the first decades of life, with a stable or slowly progressive course(1,2). [aboonline.org.br]

Corneal findings appear early in life and vision can be severely impaired between 10 and 30 years of age, even though it is a slowly progressive disease. [aboonline.org.br]

Granulomatous Myositis

Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. [ncbi.nlm.nih.gov]

progressive lower motor neuron disease. ( 18700190 ) Gdynia H.J....Sperfeld A.D. 2008 16 Paediatric contracturing granulomatous myositis. ( 18821276 ) Bowers B....Seidman [malacards.org]

Patients with granulomatous myositis usually present with slowly progressive muscle pain and weakness affecting mainly proximal muscles. [ncbi.nlm.nih.gov]

Kaposi Sarcoma of the Rectum

HAART remains the mainstay of treatment and represents the first-line therapy for limited cutaneous and slowly progressive disease. [ncbi.nlm.nih.gov]

Charcot-Marie-Tooth Disease Type 4J

[…] from slowly to rapidly progressive disease. [clinicaltrials.gov]

CMT4J may present either as an early and severe, or a late onset and more slowly progressive disease. [ncbi.nlm.nih.gov]

[…] rapidly progressive disease. [livingcmt4j.com]

Hereditary Motor and Sensory Neuropathy Type 5

Charcot-Marie-Tooth disease type 2 characterized by early childhood-onset of slowly progressive, predominantly distal, lower limb muscle weakness and atrophy, delayed motor [orpha.net]

Homepage Rare diseases Search Search for a rare disease Autosomal dominant Charcot-Marie-Tooth disease type 2O Disease definition A rare, genetic, subtype of autosomal dominant [orpha.net]

Rhinoscleroma

Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the upper respiratory tract. It is associated with Klebsiella rhinoscleromatis infection. [ncbi.nlm.nih.gov]

progressive, inflammatory disease of the upper respiratory tract. [smj.org.sg]

Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the nose and upper respiratory tract. [patientslikeme.com]

Mucopolysaccharidosis Type 3A

Individuals with MPS III may have rapidly or slowly progressing disease [Valstar et al 2010c]. [ncbi.nlm.nih.gov]

Disease course may be rapidly or slowly progressive; some individuals with an extremely attenuated disease course present in mid-to-late adulthood with early-onset dementia [ncbi.nlm.nih.gov]

Early-onset dementia is observed in some individuals, particularly those with later-onset or more slowly progressing disease. [ncbi.nlm.nih.gov]

Medullary Cystic Kidney Disease

Slowly progressive chronic kidney disease. [ncbi.nlm.nih.gov]

Uromodulin-associated kidney disease causes slowly progressive kidney disease, with the signs and symptoms usually beginning during the teenage years. [ghr.nlm.nih.gov]

This disease is autosomal dominant, meaning that it is characterized by a 50% chance of inheritance and slowly progressive chronic kidney disease that leads to the need for [en.wikipedia.org]

Myopia Type 19

Clinical Presentation Stargardt disease commonly presents in the second or third decade of life with slowly progressive bilateral visual loss, generally in the range of 20 [aao.org]

/30 to 20/200.2 The classic fundus appearance of eyes with Stargardt disease is characterized by juvenile-onset foveal atrophy, taking on a “beaten-bronze” appearance, with [aao.org]

Distal Spinal Muscular Atrophy Type 4

Slowly progressive SMA (group 1) After a median disease duration of 11 years, these patients had generalized and severe weakness. [academic.oup.com]

Almost all patients presented with late onset proximal weakness and a slowly progressive disease course without upper motor neuron signs, which were classified as FSMA. [scielo.br]

Postpolio syndrome Postpolio syndrome (PPS) is a slowly progressive disease that is rarely fatal. [emedicine.medscape.com]