Presentation
Our subsequent management and follow-up is presented. [ncbi.nlm.nih.gov]
Entire Body System
- Fever
Here, we report a case of undetectable ADA in the pleural fluid of a man presenting with chronic cough, fever and night sweats. [ncbi.nlm.nih.gov]
Basic clinical and laboratory features of filoviral hemorrhagic fever. J. Infect. Dis. 204 (suppl. 3). S810–S816 (2011) 4. Towner, J. S. et al. Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. [doi.org]
Some scientists believe that certain hypnogenic peptides might cause fevers and mobilize the body’s immune response. [thebrain.mcgill.ca]
- Intravenous Administration
For that reason, asystole was chemically induced by the intravenous administration of adenosine. The surgery was successful, and the patient was discharged from the hospital on the 10th postoperative day. [ncbi.nlm.nih.gov]
administration in people with neuropathic pain. [clinicaltrials.gov]
Comparison between fractional flow reserve (FFR) measurements after intravenous (i.v.) and intracoronary (i.c.) administration of adenosine. A, Correlation between mean FFR after i.v. (FFR iv ) and i.c. (FFR ic ) administration of adenosine. [circinterventions.ahajournals.org]
Additionally, intravenous administration of Lexiscan also increased BBB permeability in rats ( Fig. 3 B ). [doi.org]
Imaging of adenosine bolus transit following intravenous administration: insights into antiarrhythmic efficacy. Heart 1999;82(2):163-9. PubMed [ PMID: 10409529 ] PDF Lopez-Palop R, Saura D, Pinar E, et al. [aliem.com]
- Asymptomatic
KEYWORDS: Adenosine; Asymptomatic Ventricular Preexcitation; Transesophageal Electrophysiology Study [ncbi.nlm.nih.gov]
Surprisingly, however, asymptomatic AMP deaminase-deficient subjects have been reported, indicating that additional factors are likely to be involved in the development of myopathic symptoms. [orpha.net]
Halliday, A. et al. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicenter randomized trial. Lancet 376, 1074–1084 (2010). [nature.com]
- Congestive Heart Failure
Consider decreasing the recommended dose in half in patients who are presenting Congestive Heart Failure, Myocardial Infarction, shock, hypoxia, and/or hepatic or renal insufficiency. [psychology.wikia.com]
heart failure), sex, or age. [doi.org]
Cardiovascular
- Tachycardia
Adenosine terminates 90-99% of re-entrant supraventricular tachycardias but it may rarely accelerate tachycardias. Adenosine-induced tachycardia acceleration is a rare phenomenon, as only a handful of cases have been described in the literature. [ncbi.nlm.nih.gov]
(PSVT), including that associated with accessory bypass tracts (e.g., Wolff-Parkinson-White syndrome). 1 14 24 26 300 403 Drug of choice for terminating stable, regular narrow-complex tachycardias, including PSVT due to AV nodal reentrant tachycardia [drugs.com]
- Chest Pain
Recently, he developed a chest pain and underwent adenosine stress myocardial perfusion single photon emission CT (SPECT). During the adenosine stress, he felt severe chest pain and ST elevation on electrocardiogram. [ncbi.nlm.nih.gov]
Heart disease : ATP can cause reduced blood flow to the heart and chest pain. It might worsen symptoms in patients with heart diseases such as chest pain and heart attack. [webmd.com]
pain, flushing and dyspnoea). [bestbets.org]
Side effects of adenosine include: facial flushing difficulty breathing chest pain heart attack lightheadedness dizziness tingling in arms numbness nausea low blood pressure (hypotension) irregular heartbeat (palpitations) apprehension head pressure chest [rxlist.com]
- Hypotension
When administered by intravenous infusion, it can produce hypotension and atrioventricular block. [cvpharmacology.com]
The main mechanism of adenosine-induced acceleration may be the secondary sympathetic stimulation, which may be preceded by transient bradycardia and/or hypotension. [ncbi.nlm.nih.gov]
Hypotension Adenosine is a potent peripheral vasodilator and can induce significant hypotension. [drugs.com]
(except in patients with a functioning artificial pacemaker) Adenoscan: Contraindicated in bronchoconstrictive or bronchospastic lung disease (eg, asthma) Cautions Symptomatic bradycardia, cardiac arrest, heart block, heart transplant patients, HTN, hypotension [reference.medscape.com]
Verapamil is less favorable as it can cause more maternal hypotension and potential decreased perfusion to the placenta and fetus. In unstable pregnant patients, cardioversion is still the recommended treatment. [medpagetoday.com]
- Heart Disease
We examined the mechanism of adenosine-induced vasodilation in coronary arterioles from patients with heart disease. [ncbi.nlm.nih.gov]
However, although its administration is usually innocuous in patients without heart problems, serious pro-arrhythmic effects have been recorded in patients with structural heart disease.4,5 In the clinical context of ischemic heart disease and ventricular [revespcardiol.org]
Heart disease : ATP can cause reduced blood flow to the heart and chest pain. It might worsen symptoms in patients with heart diseases such as chest pain and heart attack. [webmd.com]
- Palpitations
A 41-year-old female patient presented with palpitations due to supraventricular tachycardia. The patient was treated with intravenous adenosine with resolution of the tachycardia. [ncbi.nlm.nih.gov]
Theophylline and caffeine produce their effects by several mechanisms, in particular inhibition of A1 adenosine receptors and inhibition of phosphodiesterases: Inhibition of the A1 receptors of adenosine induces: heart rate acceleration with possibility of palpitations [pharmacorama.com]
Neurologic
- Excitement
However, pro-arrhythmic effects of adenosine are also recognised, most notably in the presence of pre-excited atrial fibrillation. [ncbi.nlm.nih.gov]
Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. vasodilator agent A drug used to cause dilation [ebi.ac.uk]
Workup
Rhythm
- Torsades De Pointes
A 27 year old woman received 6 mg adenosine for PSVT, which terminated and torsades de pointes developed, persisting for 17 seconds and terminated spontaneously. [ncbi.nlm.nih.gov]
de pointes) seizure sudden difficulty breathing (bronchospasm) This document does not contain all possible side effects and others may occur. [rxlist.com]
de Pointes Seizure Bronchospasm Warnings Contraindications Hypersensitivity 2nd or 3rd degree AV block (except those on pacemakers) Sinus node disease, such as sick sinus syndrome or symptomatic bradycardia (except in patients with a functioning artificial [reference.medscape.com]
- Premature Atrial Contractions
atrial contractions and premature ventricular contractions, development of AV block, cardiac ischemia, hypotension, and prolonged asystole. [ncbi.nlm.nih.gov]
Treatment
Intravenous boluses of adenosine were injected as an attempt to slow down the arteriovenous shunting of a VGAM prior to endovascular treatment. [ncbi.nlm.nih.gov]
Prognosis
Prognosis Prognosis depends on the severity of the disease. Without treatment, SCID due to ADA deficiency that presents in infancy usually results in early death. [orpha.net]
Evaluation of A1R by MPDX-PET may be useful for predicting prognosis and understanding the compensatory and reorganization processes in hemianopia caused by organic brain damage. [ncbi.nlm.nih.gov]
The level of oral (O)SCC differentiation does not correlate with prognosis, while tumor colonization by microorganisms and chronic inflammation may well contribute to OSCC pathogenesis. [jimmunol.org]
Etiology
Etiology SCID due to ADA deficiency is caused by mutations in the ADA gene (20q13.11). The extraimmune manifestations are caused by toxic levels of purine metabolites that result from the deficiency of ADA. [orpha.net]
May be useful for diagnosis and treatment of stable, regular monomorphic wide-complex tachycardias † if the etiology of the rhythm cannot be determined. 400 401 Not effective in terminating arrhythmias not due to reentry involving the AV or sinus node [drugs.com]
Epidemiology
He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]
Summary Epidemiology SCID due to ADA deficiency accounts for 10-15% of all cases of SCID. Its annual incidence is estimated to be between 1/200,000 and 1/1,000,000 live births. Both males and females are affected. [orpha.net]
[Article in Russian; Abstract available in Russian from the publisher] Abstract Large-scale epidemiological and clinical studies have demonstrated the efficacy of metformin in oncology practice. [ncbi.nlm.nih.gov]
Top Your questions, contributions and commentaries will be answered by the lecturer or experts on the subject in the Prevention and Epidemiology list. Please fill in the form (in Spanish, Portuguese or English) and press the "Send" button. [fac.org.ar]
Pathophysiology
Adenosine is a key myocardial metabolite that elicits coronary vasodilation in a variety of pathophysiological conditions. We examined the mechanism of adenosine-induced vasodilation in coronary arterioles from patients with heart disease. [ncbi.nlm.nih.gov]
Adenosine and its receptors, pathophysiological significance and therapeutic opportunities. [ki.se]
Prevention
Adenosine prevents firing of new impulses and also prevents conduction of the impulse via the AV node. Thus it is active in SVT. Adenosine receptors The normal level of adenosine in blood ranges between 0.04 and 0.2 micromoles. [news-medical.net]
However, the patients were significantly more satisfied with adenosine because of faster prevention of hair loss and appearance of the newly grown hairs. [ncbi.nlm.nih.gov]
Thus, in regard to stress or injury, the function of adenosine is primarily that of cytoprotection preventing tissue damage during instances of hypoxia, ischemia, and seizure activity. [medchemexpress.com]