Presentation
Phylogenetic trees of the whole-genome, penton base, and fiber knob regions are presented in the top row with the hexon and its parts, “loop 1” and “conserved,” presented in the bottom row. All were generated after sequence alignments. [doi.org]
The presenting symptoms were varied in all of the groups studied and no particular presenting factor predicted the risk of associated haematuria. Haematuria is a frequent presentation requiring nephrological follow up. [adc.bmj.com]
The patients presented with sudden onset respiratory distress that progressed rapidly to respiratory failure and death. [ncbi.nlm.nih.gov]
Entire Body System
- Lymphadenopathy
Respiratory symptoms may be accompanied by pharyngitis and lymphadenopathy. Although generally mild, outbreaks of pneumonia with high mortality in children have been reported. [infectiousdiseaseadvisor.com]
Eye infections such as acute follicular conjunctivitis, often accompanied by significant periauricular lymphadenopathy, are often mild and complete recovery is common Footnote 6. [canada.ca]
Sore throat Cough, coryza Fever (moderate to high) Vomiting, diarrhea, abdominal pain Ear pain Urinary symptoms/hematuria Eye redness and pain Irritative voiding symptoms (bladder involvement) Physical Exam Fever Tonsillar erythema/exudate Cervical lymphadenopathy [unboundmedicine.com]
It's important to examine the patient for both the presence of preauricular lymphadenopathy and a follicular reaction. [reviewofophthalmology.com]
Respiratoric
- Pneumonia
The mainstay of treatment for patients with severe adenovirus pneumonia is still supportive, with the use of antivirals not apparently effective. [ncbi.nlm.nih.gov]
- Pharyngitis
pharyngitis Streptococcal pharyngitis Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. [msdmanuals.com]
We treated an immunocompetent 42-year-old man with mild adenovirus pneumonia following pharyngitis and conjunctivitis. [ncbi.nlm.nih.gov]
diarrhea, abdominal pain DDx: bacterial enteritis, bowel obstruction Diagnostic Tests & Interpretation Initial Tests (lab, imaging) Confirmation necessary only in severe cases and epidemics Viral cultures from respiratory, ocular, or fecal sources Pharyngeal [unboundmedicine.com]
The viruses cause a wide range of illnesses and symptoms such as Colds Sore throat (pharyngitis) Bronchitis Pneumonia Gastroenteritis and diarrhea Pink eye (conjunctivitis) Bladder inflammation or infection (cystitis) Inflammation of stomach and intestines [quidel.com]
Respiratory secretions, nasopharyngeal swabs are useful in diagnosing respiratory and pharyngeal infection. Conjunctival scrapings or swabs may be examined in conjunctivitis. [infectiousdiseaseadvisor.com]
Gastrointestinal
- Vomiting
IMPORTANCE The nonenveloped human adenovirus 41 causes diarrhea, vomiting, dehydration, and low-grade fever mainly in children under 2 years of age. [ncbi.nlm.nih.gov]
Babies and children with vomiting and diarrhea who can't drink enough liquids may need treatment for dehydration. [kidshealth.org]
Kids lose fluids from fever, vomiting, and diarrhea. They can get dehydrated. Water or 100% fruit juice are the best choices to keep kids hydrated. You might also try a children's solution that has electrolytes. Clear congestion. [webmd.com]
- Nausea
A 59-year-old man with T-cell prolymphocytic leukemia on alemtuzumab presented with neutropenic fever, intermittent nausea, and multiple ill-defined low attenuation foci in the liver on abdominal computed tomography scan which were suspicious for metastatic [ncbi.nlm.nih.gov]
The incidence of vomiting, nausea and respiratry symptoms was higher in Ad41 associated infections than Ad40. [doi.org]
Most of the children affected are five years old or younger and have had symptoms of gastroenteritis illness - diarrhoea and nausea - followed by jaundice or yellowing of the skin and eyes (a sign that the liver is struggling). [bbc.com]
Symptoms include fever, headache, nausea and vomiting, stiff neck, and confusion. Is Adenovirus Contagious? Adenovirus is highly contagious. [kidshealth.org]
When adenovirus infects the eyes, antibiotic eyedrops may be used to prevent secondary bacterial infection, and gastrointestinal involvement may be treated with medication to control nausea and vomiting, along with fluids to prevent or treat dehydration [nationwidechildrens.org]
- Abdominal Pain
Clinical features Symptoms caused by adenoviruses vary with the serotypes of virus, such as cough, runny nose, sore throat and fever in the respiratory tract; abdominal pain and diarrhoea in the gastrointestinal tract; and eye infection commonly known [chp.gov.hk]
pain Ear pain Urinary symptoms/hematuria Eye redness and pain Irritative voiding symptoms (bladder involvement) Physical Exam Fever Tonsillar erythema/exudate Cervical lymphadenopathy Otitis media Conjunctivitis Differential Diagnosis Characteristics [unboundmedicine.com]
The most common adverse events after adenovirus vaccine receipt are headaches, stuffy nose, sore throat, joint pain, abdominal pain, cough, nausea, diarrhea, or fever. [health.mil]
But symptoms of hepatitis or serious illness can include severe abdominal pain, prolonged fever, jaundice, or yellowing of the skin and eyes, and increased lethargy. These may indicate that you should reach out to a healthcare professional. [healthline.com]
Cardiovascular
- Heart Disease
About 97 million adults in the United States are overweight or obese, according to NIH, and face an increased risk of Type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, and other health disorders. [biologynews.net]
[…] with heart disease. visualspace / Getty Images Types of Adenoviruses More than 57 have been identified. [verywellhealth.com]
Related: 27 devastating infectious diseases In humans, adenovirus infections most commonly cause mild respiratory symptoms, but sometimes, the viruses can cause severe disease; people with compromised immune systems, existing respiratory diseases or heart [livescience.com]
Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005; 293 :43–53. [ PubMed ] [ Google Scholar ] 8. Padwal RS, Majumdar SR. [ncbi.nlm.nih.gov]
Liver, Gall & Pancreas
- Hepatomegaly
[…] that the mechanism was hypothalamic damage due to the virus. 5, 6, 7 Rous associated virus type 7 (RAV-7) was reported to induce obesity in chickens. 8, 9 RAV-7 virus-induced obesity was associated with stunting of growth, hyperlipidemia, fatty liver, hepatomegaly [doi.org]
Eyes
- Redness of Eye
Eye infections: Pinkeye (conjunctivitis) is a mild inflammation of the membranes that cover the eye and inner surfaces of the eyelids. Symptoms include red eyes, discharge, tearing, and the feeling that there's something in the eye. [kidshealth.org]
Workup
A standard diagnostic workup for children with acute hepatitis should be done locally per treating clinicians. [dph.illinois.gov]
A routine microbiological workup for infectious causes of the outbreak, including bacterial, mycoplasma, and fungal cultures, was negative. [doi.org]
Other Pathologies
- Lymphadenopathy
Respiratory symptoms may be accompanied by pharyngitis and lymphadenopathy. Although generally mild, outbreaks of pneumonia with high mortality in children have been reported. [infectiousdiseaseadvisor.com]
Eye infections such as acute follicular conjunctivitis, often accompanied by significant periauricular lymphadenopathy, are often mild and complete recovery is common Footnote 6. [canada.ca]
Sore throat Cough, coryza Fever (moderate to high) Vomiting, diarrhea, abdominal pain Ear pain Urinary symptoms/hematuria Eye redness and pain Irritative voiding symptoms (bladder involvement) Physical Exam Fever Tonsillar erythema/exudate Cervical lymphadenopathy [unboundmedicine.com]
It's important to examine the patient for both the presence of preauricular lymphadenopathy and a follicular reaction. [reviewofophthalmology.com]
Treatment
This protocol facilitates rapid and cost-effective generation of virus-specific TCLs, which appear to provide an effective treatment option. [ncbi.nlm.nih.gov]
Other treatment, depending on the symptoms, may include intravenous fluids, oxygen, and breathing treatments. How Long Do Adenovirus Infections Last? Most adenovirus infections last from a few days to a week or two. [kidshealth.org]
Prognosis
Timely diagnosis and appropriate management are essential to improve the prognosis of adenovirus hepatitis in immunocompromised patients. [ncbi.nlm.nih.gov]
The prognosis declines as the severity of disease increases. [medicinenet.com]
Etiology
LESSON: Although the most common cause that leads to HUS remains STEC, other etiologies like viral ones that may be responsible for severe enteric infection with progression into HUS should not be neglected. [ncbi.nlm.nih.gov]
The difference in testing methods should be considered when designing surveillance studies “to estimate the burden of viral etiologies of respiratory diseases,” the researchers said. [healio.com]
We analyzed 59 norovirus-positive cases with known etiology and 66 norovirus-negative cases with unknown etiology from eight different norovirus outbreaks for the presence of HAdV-52 via PCR. [doi.org]
Epidemiology
Child Child, Preschool China/epidemiology Conjunctivitis/epidemiology Conjunctivitis/etiology* Conjunctivitis/virology DNA, Viral/isolation & purification DNA, Viral/metabolism Female Genotype Humans Infant Infant, Newborn Logistic Models Male Middle [ncbi.nlm.nih.gov]
Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 53 (11), 79. https://apps.who.int/iris/handle/10665/221792 Revue Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 53 (11): 79 [apps.who.int]
Epidemiologic features: Although epidemiologic characteristics of the adenoviruses vary by type, all are transmitted by direct contact, fecal-oral transmission, and occasionally waterborne transmission. [web.archive.org]
Other epidemiological feature was as follows: EAd were detected throughout the year. The predominant serotype was Ad40 during 1980-1985, while Ad41 were observed after 1986. EAd were detected most frequently from the children aged 0-3 years. [doi.org]
Pathophysiology
We discuss the differential diagnosis and pathophysiology of allograft viral infections and concomitant rejection. [ncbi.nlm.nih.gov]
Many adenovirus infections are subclinical or asymptomatic. 15–70% of conjunctivitis worldwide Etiology and Pathophysiology DNA virus 60 to 90 nm in size, 6 species (A through F) with >50 known serotypes Adenovirus can remain dormant in lymphoreticular [unboundmedicine.com]
Pathophysiology Adenovirus is a double-stranded DNA virus that measures 70-90 nm and that has an icosahedral capsid. [emedicine.medscape.com]
There is little information about the epidemiology, pathophysiology and the usual route of infection of Ad-36. Human adenoviruses are associated with infection of the respiratory tract, gastrointestinal tract, and conjunctiva. [doi.org]
Prevention
Author information 1 Beijing Center for Disease Prevention and Control, No.16, Hepingli Middle Road, Beijing, 100013, People's Republic of China. 2 Research Centre for Preventive Medicine of Beijing, No.16, Hepingli Middle Road, Beijing, 100013, People's [ncbi.nlm.nih.gov]
For guidance to prevent adenovirus infections in healthcare settings, see Prevention & Treatment for Health Care Professionals. Treatment There is no specific treatment for people with adenovirus infection. [cdc.gov]
Additional resources The CDC—Adenoviruses Children’s Hospital of Philadelphia—Adenovirus infections APIC Infection Prevention and You—Infection Prevention Basics [apic.org]