Presentation
In the present chapter, we present a brief overview of these studies and discuss their contributions toward our understanding of the importance of miRNAs in normal and aged stem cell function in various model systems. [ncbi.nlm.nih.gov]
Comparative Biology of Aging presents trends found in comparative studies of aging. The Evolutionary Theory of Aging debates the models and hypotheses put forward to explain how aging evolved. [senescence.info]
Entire Body System
- Disability
Difficulty walking one quarter mile was used as a measure of mobility in the representative population aged 65 and older screened for the study (n = 3841) and in the one third most disabled study group (n = 1002). [ncbi.nlm.nih.gov]
T able 1 Prevalence estimates for OA in the joint region: overall and by gender Joint region Hand Hip Knee Foot OA Disabling OA OA Disabling OA OA Disabling OA OA Disabling OA Overall 26.54 12.56 19.16 10.77 30.65 14.91 23.15 11.65 (25.8, 27.3) (12.0, [doi.org]
Missoula Aging Services provides nourishing meals, nutritional education and important social contact to seniors and people with disabilities. [missoulaagingservices.org]
Caregiver Support – Supporting family and other caregivers who provide the majority of care for frail older adults and persons with disabilities. [atlantaregional.org]
- Falling
BACKGROUND: Falls in older adults with cancer are common, yet factors associated with fall-risk are not well-defined and may differ from the general geriatric population. [ncbi.nlm.nih.gov]
They are less able to protect themselves during falls. They are more likely to have side effects of drugs (such as drowsiness, loss of balance, and dizziness), which can make falls more likely. [msdmanuals.com]
- Inflammation
Aging results in chronic low grade inflammation that is associated with increased risk for disease, poor physical functioning and mortality. Strategies that reduce age-related inflammation may improve the quality of life in older adults. [ncbi.nlm.nih.gov]
Inflamm-ageing is the condition of chronic inflammation characterizing ageing. [immunityageing.com]
- Weakness
CONCLUSION: Elderly people in rural areas present good quality of life/health in the cognitive aspect, access to services, goods, habits, but awareness must be constant due to their weakness. [ncbi.nlm.nih.gov]
Their muscles (including the heart muscle) may be weak. They may lack endurance. They may have problems with balance, coordination, or agility. Their joints may be stiff. Nonetheless, age alone is not a reason to postpone or deny rehabilitation. [msdmanuals.com]
- Hunting
Ruth Archer and John Hunt, Understanding the link between sexual selection, sexual conflict and aging using crickets as a model, Experimental Gerontology, 71, (4), (2015). Jelle J. [doi.org]
[…] diamonds around any wedding cake design to add sparkle. 3.3 E-Revo Traxxas 5331 Right Front Upper & Lower Suspension Arms Revo 2.5 1/6 Holy Monk Head Carved Asura Fight Gods Series Male Head For 12" Man Figure, LEGO Ninjago Zane Ninja Minifigure 70655 Hunted [halloween-store.fr]
Tantalisingly, Prof Mock and Tony Kirkham agree that there's still more to hunt for; the actual oldest living organism on the planet almost certainly has not yet been found. [bbc.com]
The former foreign secretary won more votes than Jeremy Hunt, Michael Gove and Dominic Raab, his three closest challengers, combined. He won more than three... [timesonline.co.uk]
Respiratoric
- Aspiration
This conclusion banishes the ""fountain of youth" to the limbo of scientific impossibilities where other human aspirations, like the perpetual motion machine and Laplace's 'superman' have already been placed by other theoretical considerations. [books.google.de]
These challenges can lead to substantial gaps in access to formal health and social services, with negative implications for older residents aging-in-place and the development aspirations of resource frontier communities. [ncbi.nlm.nih.gov]
Oropharyngeal dysphagia clearly increases in the adult population and has been noted to occur in ∼50% of nursing home residents, resulting in a high frequency of aspiration pneumonia ( 5 ). [tools.wmflabs.org]
Oropharyngeal dysphagia clearly increases in the adult population and has been noted to occur in ~50% of nursing home residents, resulting in a high frequency of aspiration pneumonia ( 5 ). [web.archive.org]
Jaw & Teeth
- Dental Caries
Severe dental caries and periodontitis can lead to tooth extraction. Tooth loss impairs chewing, swallowing, and speaking, leading to nutritional deficiencies, social isolation, and depression [ 6 ]. [immunityageing.com]
Cardiovascular
- Hypertension
Subjects were on average normotensive and none was receiving hypertensive medications. [doi.org]
Sexual excitement (erection) may be influenced by diabetes mellitus, arteriosclerosis, hypertension and side effects of antihypertensive and antiviral medication. Sexual response problems can be caused by antidepressant medication. [ncbi.nlm.nih.gov]
[…] antihypertensive effect ↑ Felodipine Antihypertensive effect ↑ Isoproterenol Increased heart rate ↓ Increased ejection fraction ↓ Venodilation ↓ Nitroglycerin Venodilation ↔ Norepinephrine Acute vasoconstriction ↔ Phenylephrine Acute venoconstriction ↔ Acute hypertensive [msdmanuals.com]
- Heart Disease
[…] with exertion, and heart attack can result from coronary artery disease. [medlineplus.gov]
For example, we included 55, 35, and 43 cohort studies on diabetes, breast cancer, and ischemic heart disease, respectively, in our study compared with 16 studies on diabetes, 2 13 studies on breast cancer, 1 and nine studies on ischemic heart disease [doi.org]
FOCUS ON AGING RESEARCH Understanding the underlying mechanism of aging is the most direct way of enabling researchers to tackle common diseases of old age, such as Alzheimer’s disease, heart disease and some forms of cancer. [afar.org]
This controversy has significant public health implications because the two categories of aging theories suggest very different ways of approaching the treatment and prevention of age-related diseases such as cancer and heart disease that now cause about [programmed-aging.org]
- Vascular Disease
Toenails require special attention in older people and in people with diabetes (see Foot problems in diabetes) or peripheral vascular disease (see Foot care). [msdmanuals.com]
Other problems with the heart and blood vessels include the following: Blood clots Deep vein thrombosis Thrombophlebitis Peripheral vascular disease, resulting in intermittent pain in the legs when walking (claudication) Varicose veins Aneurysms may develop [medlineplus.gov]
The disease has a latency of many years and frequently coexists in >1 vascular bed. Its major clinical manifestations include ischemic heart disease (IHD), ischemic stroke, and peripheral arterial disease (PAD). [doi.org]
Musculoskeletal
- Osteoporosis
However, a careful reading of osteoporosis reveals how the peculiar age-related immune system remodellingitself represents the most important pathogenesis factor also for senile osteoporosis. [immunityageing.com]
Once a drug is used for treatment of any one chronic disease, its effect against other diseases (atherosclerosis, cancer, prostate enlargement, osteoporosis, insulin resistance, Alzheimer's and Parkinson's diseases, age-related macular degeneration) may [ncbi.nlm.nih.gov]
Research topics include Alzheimer's disease, Dementia, Osteoporosis, Geriatrics. The journal encourages concise rapid reporting of original research and reviews in aging. [dovepress.com]
At the UW-Madison Institute on Aging, we are jointly focused on addressing the problems of aging, which include diseases and impairments (e.g., osteoporosis, dementia, Parkinson's, glaucoma, mobility problems) and the challenges of later life (e.g., widowhood [aging.wisc.edu]
Ears
- Hearing Impairment
Introduction: The relationship between cognition and the ability to hear is well known. Due to changes in demographics, the number of people with sensorineural hearing loss and cognitive impairment is increasing. [ncbi.nlm.nih.gov]
Skin
- Ulcer
Stronger the effect of aging with urbanization were, in ascending order, for stomach cancer, ulcer, liver cancer, colon/rectum cancer, pancreas cancer, diabetes, hepatitis C, appendicitis and diarrhea. [ncbi.nlm.nih.gov]
With age, the stomach lining's capacity to resist damage decreases, which in turn may increase the risk of peptic ulcer disease, especially in people who use aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). [msdmanuals.com]
Because mouth ulcers are a common side effect of RAPA in humans, we studied the condition of the mouth in all of the marmosets in the study. No mouth ulcers were observed. [doi.org]
- Alopecia
Venafra, Androgenetic alopecia: some thoughts and views about its topical treatment, Trends in Human Hair Growth and Alopecia Research, 10.1007/978-94-011-7873-0_22, (215-218), (1989). D. [doi.org]
- Receding Hairline
Reza Pashmineh Azar, Alexander Horst Thomas, Marcus Maurer and Gerd Lindner, Asymmetry of the Receding Hairline in Men With Early Androgenetic Alopecia, Journal of Cutaneous Medicine and Surgery, 20, 6, (546), (2016). [doi.org]
- Skin Ulcer
One graft was ligated 1 month after treatment for infected overlying skin ulcer, though this graft was subsequently surgically revised with interposition graft and the covered stent portion remains functional at 19 month follow-up. [ncbi.nlm.nih.gov]
Psychiatrical
- Suggestibility
These results suggest that RAS1 and RAS2 play reciprocal roles in determining yeast longevity. RAS1 and RAS2 mRNA and protein levels declined with replicative age, suggesting a diminishing impact on yeast longevity. [ncbi.nlm.nih.gov]
Please feel free to contact me if you have any questions, ideas, comments or suggestions. Copyright © 1997 - 2014, 2018 by João Pedro de Magalhães. All rights reserved. [senescence.info]
- Fear
Our results reveal strong similarity in the utilization of visual information by younger and older adult participants in decoding the emotional expressions from faces across ages-particularly for happy and fear emotions. [ncbi.nlm.nih.gov]
[…] mobility, such as after a stroke) Additionally, older people sense thirst more slowly and less intensely than younger people do, so even those who are otherwise well may not drink enough fluids for a variety of reasons, including incontinence or the fear [msdmanuals.com]
Many feared that women would take jobs away from men who needed them. [theatlantic.com]
Neurologic
- Stroke
Partial blindness Coordination problems If you experience symptoms of a stroke you should seek medical assistance immediately! [laysamagazine.com]
Disorders that require rehabilitation (such as stroke, heart attacks, hip fracture, and limb amputation) are common among older people. [msdmanuals.com]
- Irritability
The acidity of the vagina decreases, making the genitals more likely to become irritated and infected. [msdmanuals.com]
Avoid bladder irritants. Caffeine, acidic foods, alcohol and carbonated beverages can make incontinence worse. Avoid constipation. Eat more fiber and take other steps to avoid constipation, which can worsen incontinence. [mayoclinic.org]
This thinner and weaker oral mucosa may be more vulnerable to local irritation, resulting in a greater risk of candidal infection and/or reactivation of the varicella-zoster infection[ 6 ]. [immunityageing.com]
However, irritant and contact allergic reactions may develop (commonly due to p- phenylenediamine) and can result in dermatitis and sometimes hair loss. [65] Recent advances in the management of aging hair and scalp are anti-aging compounds. [doi.org]
- Agitation
Growing old समय व्यतीत होने के साथ-साथ शरीर में रचना सम्बन्धी परिवर्तन, वयोवृद्धि Agitation Excessive physical activity अत्यधिक शारीरिक सक्रियता, विलोडन Agitographia Writing very rapidly बहुत जल्दी-जल्दी बोलना Agitophasia Agitolalia speaking very quickly [drdata.in]
After which the plate was again sealed and incubated with agitation in darkness for 30 minutes at room temperature. [doi.org]
Lysis was performed at room temperature for 5 minutes with agitation, and the samples were then returned to ice. Using gel loading pipette tips, the cell extract was removed from alginate beads and placed into a clean Eppendorf tube. [ncbi.nlm.nih.gov]
- Insomnia
Both sexes suffer from insomnia. The relationship between personality traits and pain was only affected to a minor extent by insomnia. [ncbi.nlm.nih.gov]
"Many studies have shown insomnia leads to reduced test performance, school performance, increased risk of accidents and effects on the immune system. There is a wealth of information documenting those effects." Kripke disagrees. [edition.cnn.com]
Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in adults and in older adults 55 + years. Health Psychology. 2004; in press. Google Scholar [doi.org]
Treatment
We also briefly reviewed available data on the treatment of arterial thrombosis in FVII deficiency. [ncbi.nlm.nih.gov]
Prognosis
Doctors Give Medicare’s Proposal To Pay For Telemedicine Poor Prognosis By Phil Galewitz October 10, 2018 Federal officials are proposing that Medicare pay doctors for a 10-minute “check-in” call with beneficiaries. [khn.org]
In the largest tumor group in our material, prostate cancer, the blood TL ≥9 years before diagnosis seemed to indicate a poor prognosis. [doi.org]
Etiology
Aging individuals can develop generalized, exquisitely-pruritic, eczematous eruptions of uncertain etiology that can be therapeutically-refractory and life-altering. [ncbi.nlm.nih.gov]
Introduction Among those with depression, it is older adults who are most likely to attempt and complete suicide.[ 1 ] The role of concomitant physical disease, and the etiology of depression among seniors are poorly understood and confusing. [doi.org]
Reiter WJ, Schatzl G, Mark I et al. (2001) Dehydroepiandrosterone in the treatment of erectile dysfunction in patients with different organic etiologies. Urol Res 29: 278–281 PubMed CrossRef Google Scholar 46. [springerlink.com]
Epidemiology
Author information 1 Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory [ncbi.nlm.nih.gov]
Article Navigation 1 Division of Sleep Medicine 3 Departments of Epidemiology 5 Harvard Medical School, Boston, Mass * Address correspondence to: Sanjay R. [doi.org]
Pathophysiology
Tetraploidy, a condition in which a cell has four homologous sets of chromosomes, is often seen as a natural physiological condition but is also frequently seen in pathophysiological conditions such as cancer. [ncbi.nlm.nih.gov]
Prevention
Even though new trials are ongoing, the recognition of this syndrome is essential to prevent cardiovascular and cerebrovascular complications. [ncbi.nlm.nih.gov]
These mechanisms therefore represent potential therapeutic targets in the prevention and treatment of such pathologies. Copyright © 2011 Cold Spring Harbor Laboratory Press; all rights reserved [doi.org]
Therefore, investigation on sequence specificity of DNA damage would provide clues on the biological significance of DNA damage which in turn may be beneficial for cancer prevention strategy. [ci.nii.ac.jp]