Presentation
We present a case of C. sordellii bacteraemia and septic shock in an immunocompromised patient who was recently diagnosed with pleomorphic gluteal sarcoma. [ncbi.nlm.nih.gov]
Microbiome profiling is the process of understanding the species present in a microbial community, also known as the microbiome. The microbiome can be present in many different environments, including the human gut. [news-medical.net]
Entire Body System
- Weakness
A 58-year-old Japanese man with an unremarkable medical history presented with a 3-day history of mild weakness in both legs, and experienced paraplegia and paresthesia a day before admission. [ncbi.nlm.nih.gov]
- Asymptomatic
Moreover, antimicrobial therapy increases the likelihood of isolating C difficile from the fecal flora: C difficile can be isolated from the feces of approximately 20 to 40% of asymptomatic hospitalized patients who are receiving antimicrobial therapy [ncbi.nlm.nih.gov]
Respiratoric
Gastrointestinal
- Vomiting
Her symptoms included severe abdominal cramping, vomiting, and. .. Elissa Meites, M.D., M.P.H. Suzanne Zane, D.V.M. Carolyn Gould, M.D. [doi.org]
In other people, a toxin produced by C. difficile causes diarrhea, abdominal pain, severe inflammation of the colon (colitis), fever, an elevated white blood count, vomiting and dehydration. [medicinenet.com]
- Nausea
Nausea is also a common symptom. Fever and vomiting are not normally symptoms of poisoning by Clostridium perfringens toxins. Illness from Clostridium perferingens generally lasts around 24 hours, and is rarely fatal. [foodborneillness.com]
The symptoms of Clostridium difficile -associated disease include: watery diarrhea fever loss of appetite nausea abdominal pain and tenderness In rare cases, Clostridium difficile can cause death. [ccohs.ca]
Other symptoms may include nausea, vomiting, abdominal pain, and fever. Symptom onset is usually sudden and occurs within 8-12 hours, but can take up to 24 hours from ingestion. Duration of symptoms is typically less than 24 hours. [bccdc.ca]
Other symptoms of a serious infection include: Diarrhea more than 10 times a day Severe cramping Fever Nausea Loss of appetite/weight loss Dehydration Rapid heart rate It’s fairly common to have mild diarrhea when starting an antibiotic. [webmd.com]
Signs and symptoms Mild, self-limiting symptoms can include: diarrhoea (watery or sometimes bloody) fever loss of appetite nausea abdominal pain A serious form of the disease, known as pseudomembranous colitis (severe inflammation of the lining of the [sahealth.sa.gov.au]
- Constipation
Constipation may precede the illness by several weeks. An electromyogram pattern of brief, small-amplitude overabundant motor reaction potentials often is seen. [ncbi.nlm.nih.gov]
- Failure to Thrive
For infant botulism, additional syndromes enter into the differential diagnosis: failure to thrive, acute infantile polyneuropathy, dehydration, and various hereditary and metabolic disorders. [ncbi.nlm.nih.gov]
- Abdominal Cramps
Her symptoms included severe abdominal cramping, vomiting, and. .. Elissa Meites, M.D., M.P.H. Suzanne Zane, D.V.M. Carolyn Gould, M.D. [doi.org]
The bacteria then elaborate the enterotoxin that causes the characteristic symptoms of diarrhea and abdominal cramping. [textbookofbacteriology.net]
Cardiovascular
- Hypotension
Immediately after the procedure, she developed refractory hypotension, severe tachycardia, pulmonary edema, and leukemoid reaction (white blood cell count 80×10/L). [ncbi.nlm.nih.gov]
Neurologic
- Irritability
[…] composition, known as dysbiosis, has been implicated in chronic gut, and perhaps also systemic, immune disorders, such as in the pathogenesis of inflammatory bowel diseases (IBD), and other gastrointestinal disorders, including gastritis, peptic ulcer, irritable [doi.org]
Workup
Microbiology
- Gram-Positive Bacteria
Clostridium, genus of rod-shaped, usually gram-positive bacteria, members of which are found in soil, water, and the intestinal tracts of humans and other animals. Most species grow only in the complete absence of oxygen. [britannica.com]
Clostridium is a genus of Gram-positive bacteria, which includes several significant human pathogens, including the causative agent of botulism. [en.wikipedia.org]
In this scenario, gut commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes. [doi.org]
Laboratory
- Leukocytosis
CSTS is marked by the rapid onset of severe illness with shock (edema, effusion, profound leukocytosis and hemoconcentration, followed by shock and multiorgan failure), and often occurs in previously healthy persons. [canada.ca]
Hypoalbuminemia and leukocytosis are common findings. Pathology involves only the colon where there may be disruption of brush border membranes followed by extensive damage to the mucosa. [ncbi.nlm.nih.gov]
Treatment
We discuss treatment, causes and mechanisms of this rare complication from this treatment and review the bibliography about mechanisms for the different types of immunological reactions that may occur after treatment with collagenase Clostridium histolyticum [ncbi.nlm.nih.gov]
[…] as treatment for primary C. difficile infection. [nejm.org]
Prognosis
Infectious involvement of the aorta and associated vascular structures portends a poor prognosis with a 57% mortality rate. Our case and updated review demonstrates the implications of C. septicum vascular seeding and subsequent treatment outcomes. [ncbi.nlm.nih.gov]
Etiology
Clostridium difficile, a Gram positive spore-forming anaerobe, is considered a frequent etiological agent; recently, C. perfringens has also been implicated and may act, synergically with C. difficile. [dialnet.unirioja.es]
Inhalt CHAPTER I 1 CHAPTER II 33 CHAPTER III 73 BACTERIA AND FERMENTATION 92 BACTERIA IN THE SOIL 118 CHAPTER VI 151 BACTERIA IN MILK AND MILK PKODUCTS 178 BACTERIA IN OTHER FOODS 253 CHAPTER IX 280 CHAPTER X 323 THE ETIOLOGY OF TROPICAL DISEASES 370 [books.google.com]
The etiology of NEC is not understood, although bacterial colonization of the gut is believed to play a role Footnote 11. Clostridium spp. have been particularly associated with more severe cases of NEC Footnote 4, Footnote 11. [canada.ca]
C. difficile is considered the etiologic agent of PMC and the major cause of antibiotic-associated diarrhea in adults, but the attribution of this organism to enteric diseases in children is less clear (Karlsson et al. 2000). [scielo.br]
Spores are rare in cultures of C perfringens, the most common etiologic agent of these diseases. [ncbi.nlm.nih.gov]
Epidemiology
Biology and Epidemiology 3.2.1.1.2. Chemotherapy 3.2.1.2. American Trypanosomiasis 3.2.1.2.1. Biology and Epidemiology 3.2.1.2.2. Chemotherapy 3.2.1.3. Leishmaniasis 3.2.1.3.1. Biology and Epidemiology 3.2.1.3.2. Chemotherapy 3.2.2. [doi.org]
Guidance for Management in Acute Care Settings (2013 update) Clostridium difficile : Infection Prevention and Control Guidance for Management in Long-term Care Facilities (2013) Infectious Diseases Society of America (IDSA) / Society for Healthcare Epidemiology [ecdc.europa.eu]
Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infection Control and Hospital Epidemiology. [labtestsonline.it]
Pathophysiology
Since the metalloproteinase profile and activity of the human gut microbiota remains uncharacterized, we explored whether bacterial-derived proteases might have the potential to contribute to physiological or pathophysiological processes within the gut [doi.org]
Cervical dystonia pathophysiology and treatment options" Drugs 2001;61:1921–1943. ^ “ Providing for a Sustainable Energy Future ”. Bioengineering Resources, inc. 2007年5月21日 閲覧。 ^ Mengesha et al. (2009). “Clostridia in Anti-tumor Therapy”. [wikiwand.com]
Tetanus: pathophysiology, management, and prophylaxis. Disease-A-Month. 1991; 37 :545. [ PubMed : 1874121 ] Coffield JA, Considine RV, Simpson LL. Clostridial neurotoxins in the age of molecular medicine. [ncbi.nlm.nih.gov]
Prevention
Infection: Infection Prevention and Control Guidance for Management in Acute Care Settings (2013 update) Clostridium difficile : Infection Prevention and Control Guidance for Management in Long-term Care Facilities (2013) Infectious Diseases Society of [ecdc.europa.eu]
How can Clostridium difficile transmission be prevented in hospitals and other health care settings? Frequent hand washing (with soap and water) is an effective way to prevent the spread of the bacteria. [ccohs.ca]
If you cannot drink enough fluids to prevent dehydration, call your doctor. How Do I Prevent It? Thoroughly cook foods, particularly meat, poultry, and gravies, to a safe internal temperature. [foodsafety.gov]
Prevention The most important measure to prevent the emergence of new strains of C. difficile in Australia is reducing the unnecessary use of antibiotics, especially those known to be closely linked to CDI. [sahealth.sa.gov.au]