Presentation
Neurologic
- Stroke
N Engl J Med 27: 2687–2695 CrossRef Google Scholar Gould DB et al. (2006) Role of COL4A1 in small-vessel disease and hemorrhagic stroke. [link.springer.com]
[…] and leukoencephalopathy (CADASIL), a Notch3 dominant mutation-induced cerebral small vascular disease, is characterized by progressive degeneration of vascular smooth muscle cells (vSMCs) of small arteries in the brain, leading to recurrent ischemic stroke [academia.edu]
Treatment
To date, no treatment can stop or delay the progression of this disease. [academia.edu]