Esophagitis is a condition, characterized by inflammation of the esophagus. It can either be acute, or chronic in nature.
Presentation
The condition of esophagitis, presents with the following signs and symptoms [7]:
- Swallowing becomes difficult and very painful
- Development of heartburn and regurgitation
- Experiencing pain in chest during eating
- Food impaction, which occurs when food gets stuck in the esophagus during swallowing
Workup
The following tests would be employed, for diagnosing the condition of esophagitis:
- Physical examination: A preliminary physical examination, which includes a question and answer session to understand the symptoms, is carried out.
- Barium X-ray: In this test, the individual is given solution of barium to drink, or is given a pill coated with barium. Barium evenly coats the esophageal lining, and the stomach, which makes it possible to clearly view the abnormalities inside the organs. An X-ray is conducted, which helps in analyzing the esophagus.
- Endoscopy: Endoscope is used for viewing the internal of the esophagus, to determine any unusual development. During this process, a sample of the tissue is also taken for biopsy. The sample is tested for viral agents, or presence of any abnormal cell development [8].
Treatment
The goal of treatment involves effective management of the symptoms, and treating the underlying disease conditions. Methods for treating esophagitis, depend on the cause of the condition. Following methods are employed to treat esophagitis:
- Reflux esophagitis is usually treated with over the counter medications that would help control gastrophageal reflux. If these do not work, then prescription strength medications, that include H2-receptor blockers, can be administered. When other modes of treatment fail to show any positive effect then surgery is the last resort [9].
- Eosinophilic esophagitis is treated with proton pump inhibitors, that would help reduce the allergic reactions [10]. Topical swallowed steroids can also be used, along with the 6–food elimination diet, in which individuals are asked to abstain from certain foods triggering allergies [11]. Surgical procedures, such as fundoplication may be employed, for correcting esophagitis.
- In the case of infectious esophagitis, antibiotics are administered to treat the causative agent. Various causative agents such as bacteria, virus, fungi and parasite can be effectively treated with medications.
- Drug-induced esophagitis is treated by avoiding medications, which cause damage, and irritation to the tissues of the esophagus. Administration of alternative drug, or taking liquid form of the same pill, can be considered. Individuals are also advised to stand, or sit for 30 minutes, after ingestion of the pill.
Prognosis
The prognosis of the condition is usually favorable, and patients usually respond to treatment. For individuals with compromised immunity, recovery period will be pretty long. However, if esophagitis has induced significant changes in the cells of the esophagus, then chances of developing cancer in the future increases [6].
Etiology
In majority of the cases, back flow of the stomach acids into the esophagus, is the major cause of esophagitis. In addition, other factors such as infections, underlying disease conditions, allergies and medications, can also predispose an individual to develop the condition. The nature of the causative factor gives rise to a specific type of esophagitis.
Back flow of acidic contents of stomach into the esophagus, causes gastrophageal reflux to develop. This in turn, leads to inflammation of the esophagus, causing esophagitis. Certain medications, if not gulped with enough water, can cause its remnants to remain in the lining of the esophagus, irritating the tissues. Such a condition is termed as drug-induced esophagitis [2].
Epidemiology
Esophagitis is a common occurrence amongst adults, children are seldom affected [3]. Reflux esophagitis and candida esophagitis are the most common forms of esophagitis. Symptoms of esophageal reflux occur in about 33 – 44% of population. Infectious esophagitis is majorly caused due to Herpes virus, and commonly occurs in those individuals with an underlying disease conditions, such as AIDS, lymphoma and leukemia [4].
Pathophysiology
The pathophysiology of esophagitis depends on the nature of the cause. However, the basic mechanism behind causation of inflammation of the esophagus, remains the same. Due to certain triggering factors, such as infection, drugs or gastrophageal reflux, irritation and damage to the tissues of the esophagus are caused. Such a phenomenon, favors the development of inflammation of the esophagus, which in turn, paves way for development of several unpleasant symptoms [5].
Prevention
It is not always possible to prevent esophagitis. However, affected individuals can prevent its recurrence, by following those methods that have triggered previous bouts of esophagitis. It is necessary to avoid those medications, that can cause irritation in the esophageal lining. Also, avoiding direct contact with individuals, living with Herpes virus is also important.
Summary
Esophagitis is a painful condition, which can cause difficulty in swallowing of food in affected individuals. Some of the common forms of esophagitis include infectious esophagitis, eosinophilic esophagitis, pill esophagitis, reflux esophagitis and candida esophagitis. Of these, candida esophagitis is the most common form. Adults are more prone to develop the condition than children [1].
Patient Information
Definition: Esophagitis is a condition, wherein there is inflammation of esophagus, due to damage to its tissue by certain factors. Such a type of condition is more common amongst the adult population.
Cause: Gastropahgeal reflux, a condition characterized by back flow of the stomach contents to the esopahagus, is the most common cause of esopahgitis. In addition, certain types of drugs, allergic reactions, and infections can also lead to development of esophagitis.
Symptoms: Symptoms of esophagitis include difficulty and pain, while swallowing food, heartburn, chest pain, acid regurgitation and food impaction.
Diagnosis: Various tests will be required to diagnose the condition of esophagitis and also to determine development of future complications. Diagnosis is done through the barium X-ray test, and endoscopy. These procedures help in proper viewing of the internal features of esophagus, to look for the presence of abnormalities.
Treatment: The type of treatment employed, depends on the type of esophagitis that has set in. For reflux esophagitis, over the counter medication are prescribed for preventing gastrophageal reflux. In addition, prescription strength medications, containing H2-receptor blockers are administered. For infectious esophagitis, antibiotics are prescribed for treating the infections.
References
- Winstead NS, Bulat R. Pill Esophagitis. Curr Treat Options Gastroenterol. Feb 2004;7(1):71-76.
- Zografos GN, Georgiadou D, Thomas D, et al. Drug-induced esophagitis. Dis Esophagus 2009; 22:633.
- Nurko S, Rosen R, Furuta GT. Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry. Am J Gastroenterol. Dec 2009;104(12):3050-7.
- Levine MS, Laufer I, Kressel HY, Friedman HM. Herpes esophagitis. AJR Am J Roentgenol. May 1981;136(5):863-6.
- Dent J, Dodds WJ, Friedman RH, et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980; 65:256.
- Nonevski IT, Downs-Kelly E, Falk GW. Eosinophilic esophagitis: an increasingly recognized cause of dysphagia, food impaction, and refractory heartburn. Cleve Clin J Med. Sep 2008;75(9):623-6, 629-33.
- Geagea A, Cellier C. Scope of drug-induced, infectious and allergic esophageal injury. Curr Opin Gastroenterol 2008; 24:496.
- Dellon ES, Gonsalves N, Hirano I, et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol. May 2013;108(5):679-92; quiz 693
- Donnellan C, Sharma N, Preston C, Moayyedi P. Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease. Cochrane Database Syst Rev. Apr 18 2005;CD003245.
- Schroeder S, Capocelli KE, Masterson JC, et al. Effect of proton pump inhibitor on esophageal eosinophilia. J Pediatr Gastroenterol Nutr 2013; 56:166.
- Reuters Health. Elimination diet helps adult eosinophilic esophagitis: study. Medscape Medical News. February 15, 2013.