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2.1
Gynecomastia
Enlargement male Breast
Gynecomastia is the enlargement of breast tissue in males. It can affect one or both breasts.

Images

WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, Fair use

Presentation

Patients with gynecomastia typically present with a noticeable enlargement of one or both breasts. The condition can be symmetrical or asymmetrical and may be accompanied by tenderness or sensitivity in the breast area. The enlargement is usually soft and may feel rubbery or firm. In some cases, patients may also notice a small, disc-like lump beneath the nipple. It is important to differentiate gynecomastia from other conditions such as breast cancer or pseudogynecomastia, which is fat accumulation without glandular proliferation.

Workup

The workup for gynecomastia involves a thorough medical history and physical examination. Key aspects of the history include the duration of breast enlargement, associated symptoms, and any medications or substances that could contribute to the condition. Blood tests may be conducted to assess hormone levels, liver function, and kidney function. Imaging studies, such as ultrasound or mammography, may be used to evaluate the breast tissue and rule out other conditions. In some cases, a biopsy may be necessary to exclude malignancy.

Treatment

Treatment for gynecomastia depends on the underlying cause and the severity of the condition. In many cases, no treatment is necessary, and the condition resolves on its own. If gynecomastia is caused by medication or substance use, discontinuing the offending agent may lead to improvement. For persistent or bothersome cases, medical treatments such as hormone therapy or medications like tamoxifen may be considered. Surgical options, including liposuction or mastectomy, are available for severe cases or when other treatments are ineffective.

Prognosis

The prognosis for gynecomastia is generally favorable, especially when the underlying cause is identified and addressed. In adolescents, the condition often resolves spontaneously as hormone levels stabilize. For adults, the outcome depends on the cause and the effectiveness of treatment. While gynecomastia itself is not life-threatening, addressing any psychological impact is important for overall well-being.

Etiology

Gynecomastia can result from various factors that disrupt the balance between estrogen and testosterone. Common causes include hormonal changes during puberty, aging, and certain medical conditions such as liver or kidney disease. Medications, such as anti-androgens, anabolic steroids, and some antidepressants, can also contribute to the development of gynecomastia. Additionally, lifestyle factors like alcohol and drug use may play a role.

Epidemiology

Gynecomastia is a common condition, affecting up to 70% of adolescent boys during puberty. It is also prevalent in older men, with an estimated 30% to 70% experiencing some degree of breast enlargement. The condition can occur in newborns due to maternal hormones but typically resolves within a few weeks. Gynecomastia is less common in adult men but can occur due to various medical or lifestyle factors.

Pathophysiology

The pathophysiology of gynecomastia involves an imbalance between estrogen and testosterone levels. Estrogen promotes the growth of breast tissue, while testosterone inhibits it. When the ratio of these hormones is disrupted, either due to increased estrogen or decreased testosterone, breast tissue can enlarge. This imbalance can be caused by physiological changes, medications, or underlying health conditions.

Prevention

Preventing gynecomastia involves addressing modifiable risk factors. This includes avoiding the use of substances known to affect hormone levels, such as anabolic steroids, alcohol, and certain drugs. Maintaining a healthy lifestyle with regular exercise and a balanced diet can also help. For those on medications that may cause gynecomastia, discussing alternatives with a healthcare provider is advisable.

Summary

Gynecomastia is a common condition characterized by the enlargement of breast tissue in males due to hormonal imbalances. While often benign, it can cause psychological distress. Diagnosis involves a thorough evaluation to rule out other conditions, and treatment depends on the underlying cause and severity. The prognosis is generally good, especially when the cause is identified and managed. Understanding the etiology and pathophysiology is key to prevention and effective treatment.

Patient Information

If you or someone you know is experiencing breast enlargement, it is important to understand that gynecomastia is a common and usually benign condition. It can occur at any age and is often related to hormonal changes. While it may cause discomfort or embarrassment, there are effective treatments available. Discussing symptoms with a healthcare provider can help determine the cause and appropriate management. Remember, you are not alone, and support is available.

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