Presentation
The present results warrant administration of larger doses than those used in the present investigation owing to the apparently fast absorption. [ugeskriftet.dk]
A 40-month-old female infant presented to our emergency department due to failure to awaken. The patient was assessed in terms of etiology of coma, and her history revealed that she had been given a 100 mg phenobarbital pill instead of 15 mg. [go.gale.com]
Editor—We present data from a patient with severe phenobarbital poisoning who we treated with charcoal haemoperfusion and multiple-dose activated charcoal (MDAC). [academic.oup.com]
The thrombocyte loss, however, presents the additional problem that the recovery may be delayed. A precipitous fall of platelets may be prevented by gentle manipulation of the resin column during the saline rinse of the resin beads. [jpet.aspetjournals.org]
Entire Body System
- Epilepsy
Primidone (Mysoline), 5-phenyl-5-ethylhexahydropyrimidine-4,6-dione, is an anticonvulsive agent which has been used successfully in the treatment of grand mal epilepsy and is reported to have controlled seizures in cases refractive to other anticonvulsant [jamanetwork.com]
How phenobarbital revolutionized epilepsy therapy: The story of phenobarbital therapy in epilepsy in the last 100 years. Epilepsia 2012;53:26-39. 2. Mactier R, Laliberté M, Mardini J, Ghannoum M, Lavergne V, Gosselin S, et al. [actamedicainternational.com]
Arslan Phenobarbital continues to be widely used in childhood epilepsy. Incorrect drug prescription can sometimes lead to intoxication, particularly in young children. [go.gale.com]
However, it has not been established that prevention of febrile seizures influences the subsequent development of epilepsy. [rxlist.com]
Therefore, they are effective adjuncts in the treatment of epilepsy. The high doses of barbiturates used in the care of neurocritical patients have in recent years been reported to possibly lead to the accumulation of propylene glycol. [emedicine.medscape.com]
- Hypothermia
Signs at presentation were ventilatory frequency 12 bpm, pulse oximetry 100% ( 100%), hypotension (88/58 mm Hg), heart rate 64 beats min−1, Glasgow coma score 3/15, miosis (2 mm bilaterally), areflexia, and hypothermia (33.1°C). [academic.oup.com]
- Gastric Lavage
If emesis is contraindicated, gastric lavage may be performed with a cuffed endotracheal tube in place with the patient in the face down position. Activated charcoal may be left in the emptied stomach and a saline cathartic administered. 5. [rxlist.com]
Neurologic
- Irritability
Faulty judgment Lack of coordination Shallow breathing Slow, slurred speech Sluggishness Staggering Excessive and long-term use of barbiturates, such as phenobarbital, may produce the following chronic symptoms: Changes in alertness Decreased functioning Irritability [medlineplus.gov]
Mental signs of chronic intoxication include confusion, poor judgment, irritability, insomnia, and somatic complaints. Symptoms of phenobarbital dependence are similar to those of chronic alcoholism. [rxlist.com]
- Areflexia
Signs at presentation were ventilatory frequency 12 bpm, pulse oximetry 100% ( 100%), hypotension (88/58 mm Hg), heart rate 64 beats min−1, Glasgow coma score 3/15, miosis (2 mm bilaterally), areflexia, and hypothermia (33.1°C). [academic.oup.com]
Acute overdosage with barbiturates is manifested by CNS and respiratory depression which may progress to Cheyne- Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation [rxlist.com]
Treatment
At the conclusion of the 5 h treatment, the serum phenobarbital concentration was 214 µmol litre−1. [academic.oup.com]
No serious complications to the phenobarbital treatment were observed. [ugeskriftet.dk]
No rebound effect was seen after cessation of the treatment. The patient fully recovered and was discharged 72 h after admission. [tandfonline.com]
The important advantages and disadvantages of this new form of treatment are discussed. Footnotes Received August 21, 1959. [jpet.aspetjournals.org]
The first is that extracorporeal treatment methods should only be used in the case of long-acting barbiturates. [actamedicainternational.com]
Prognosis
However, the relevance of this classification system in terms of prognosis remains to be well defined as the agents’ duration of action is only partially correlated with half-life (the remaining differences are accounted for with tissue binding and distribution [emedicine.medscape.com]
Etiology
The patient was assessed in terms of etiology of coma, and her history revealed that she had been given a 100 mg phenobarbital pill instead of 15 mg. Her blood phenobarbital level was high (>80 mg/dl). [go.gale.com]
Prevention
A precipitous fall of platelets may be prevented by gentle manipulation of the resin column during the saline rinse of the resin beads. The important advantages and disadvantages of this new form of treatment are discussed. [jpet.aspetjournals.org]
However, it has not been established that prevention of febrile seizures influences the subsequent development of epilepsy. [rxlist.com]
This finding clearly increases the clinical usefulness of phenobarbital, if this drug is chosen, and it allows an aggressive treatment strategy aiming at quickly alleviating the physical withdrawal symptoms and preventing the development of DT. [ugeskriftet.dk]