Presentation
In the present communication, we present two patients (one with multiple sclerosis and the other with Parkinson's disease) in whom treatment with magnetic fields produced behavioral effects which paralleled those observed in REM-sleep-deprived animals [ncbi.nlm.nih.gov]
Entire Body System
- Fatigue
Therefore, the study aimed to investigate the effects of 24-h sleep deprivation on mood, fatigue, and airline pilot competencies. [ncbi.nlm.nih.gov]
[…] pilot is too fatigued to fly. [web.archive.org]
[…] of fatigue despite evidence of increased risk to health and safety. 4 5 This has led to calls for better information on the extent and consequences of the effects of fatigue on performance. 6 The problem, in practice, is at what level of fatigue does [doi.org]
- Weight Gain
A number of studies have observed people who sleep five hours or less are more prone to weight gain and weight-related diseases such as type-2 diabetes. [dailymail.co.uk]
Sleep loss is currently proposed to disturb endocrine regulation of energy homeostasis leading to weight gain and obesity. [ncbi.nlm.nih.gov]
Short sleep duration and weight gain: a systematic review. Obesity(Silver Spring). 2008; 16:643-53. 2. PatelSR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between reduced sleep and weight gain in women. [hsph.harvard.edu]
These two changes could lead to diabetes and weight gain. Lack of sleep also increases inflammation, thought to be a key element in the development of heart disease. [web.archive.org]
- Inflammation
Genes related to circadian rhythms, metabolism, inflammation, immune response and stress were all affected by the experiment. [abc.net.au]
CONCLUSIONS: This study suggests that JTW has the beneficial effects of improving sleep, inflammation and insulin sensitivity. The mechanism appears to be related to the modulation of circadian clock and inflammation genes expressions in PBMC. [ncbi.nlm.nih.gov]
Proctosigmoiditis is a result of chronic inflammation in the colon, like all types of ulcerative colitis. This inflammation is the result of an immune response. Doctors don’t know what triggers this immune response. [healthline.com]
- Weakness
Some patients will experience only pain, while others may also suffer from weakness in their arms or legs. The weakness may be mild or may progress to paralysis in a relatively short period of time. [lifebridgehealth.org]
Metastasis to the spine can lead to significant adverse effects, including numbness/tingling, weakness, pain and incontinence. A significant proportion of patients who develop spinal metastasis will develop one or more of these symptoms. [dukecancerinstitute.org]
There’s an important weakness in the experiment, however, in that participants didn’t face any penalty for signing the confession. [arstechnica.com]
Spinal metastases can cause neurologic symptoms including weakness, sensory loss, strange sensations, difficulty with or inability to walk, or bowel and bladder dysfunction. [urmc.rochester.edu]
At the expressed inflammatory process there is a weakness, the person grows thin, body temperature increases. Inflammatory process at a chronic sigmoiditis sometimes extends to a visceral peritoneum with development of a perisigmoiditis. [en.medicalmed.de]
- Crying
These changes were also associated with the up-regulation of Cry1 mRNA and Cry 2 mRNA and the down-regulation of NF-κB mRNA expression in PBMC. [ncbi.nlm.nih.gov]
(Find out how much sleep you really need .) 5 of 6 Weird things make you cry Do those ballads on American Idol move you to tears? Try going to bed earlier. [prevention.com]
Husband Adrian will often sleep on the sofa when he gets in from work, so he doesn't hear his kids crying Many nights he'll crash out on the sofa so as not to disturb the children and me - but it means he often doesn't hear their cries, so I have to tend [dailymail.co.uk]
You ugly cry over every little thing Harvard Medical School also found that a good night's sleep promotes emotional resilience, while lack of sleep leads to emotional vulnerability. [bustle.com]
Cardiovascular
- Hypertension
SD could induce autonomic nervous dysfunction, hypertension, arrhythmia, hormonal dysregulation, oxidative stress, endothelial dysfunction, inflammation and metabolic disorder in CHD patients. [ncbi.nlm.nih.gov]
Heart Disease and Hypertension Studies have found that a single night of inadequate sleep in people who have existing hypertension can cause elevated blood pressure throughout the following day. [web.archive.org]
Hypertension Research, 10.1038/hr.2017.75, 40, 12, (947-963), (2017). [doi.org]
Musculoskeletal
- Arthritis
The pain may be mild at first and is often mistaken for arthritis or a mild back strain. It may be treatable initially with acetaminophen or ibuprofen but may become more constant and severe over days or weeks. [lifebridgehealth.org]
Long-term sleep loss is occasionally caused by environmental factors – your job, if you’re a night-shift worker; where you live, if it’s in a noisy area – but it more commonly stems from medical conditions such as arthritis, diabetes, epilepsy, ulcers [ccmr.cornell.edu]
Sleep deficiency can contribute to: kidney stones, IBS, fertility problems, heart disease, headaches/migraines, arthritis, thyroid disorders and many other conditions. [draxe.com]
These can be from too much caffeine, an irregular schedule, anxiety or depression, physical problems such as arthritis, use of other medications, and so on—and only a careful evaluation by a doctor experienced in sleep medicine can uncover the causes. [hbr.org]
Powers, A review of biobehavioral research in juvenile primary fibromyalgia syndrome, Arthritis Care & Research, 13, 6, (388-397), (2001). [dx.doi.org]
Eyes
- Blurred Vision
Lack of sleep can cause myriad symptoms: aching muscles, blurred vision, depression, color blindness, drowsiness, loss of concentration, weak immune system, dizziness, dark circles of the eyes, fainting, confusion, hallucinations, symptoms of drunkenness [world-of-lucid-dreaming.com]
Signs of chronic sleep deprivation can also include frequent infections/illnesses, blurred vision, changes in appetite, and depression. [ccmr.cornell.edu]
Psychiatrical
- Suggestibility
BACKGROUND: Sleep deprivation has been associated with obesity among adults, and accumulating data suggests that stearoyl-CoA desaturase 1 (SCD1) expression has a relevant impact on fatty acid (FA) composition of lipid pools and obesity. [ncbi.nlm.nih.gov]
That could mean that the more sleep-deprived someone feels, the more impaired their judgment is (as the researchers suggest). [arstechnica.com]
The evening condition (i.e. at the end of day spent awake) was intermediate between the two, suggesting that wakefulness causes progressive changes that build up over time. [blogs.discovermagazine.com]
[…] of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA 4 Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA Abstract Many behavioral and electrophysiological studies in animals and humans have suggested [dx.doi.org]
- Mood Swings
These can include forgetfulness, inattentiveness, being less able to fight off infections, and even mood swings and depression. Facts about sleep deprivation Sleep deprivation is becoming more common. [columbianeurology.org]
In humans, lack of sleep leads to impaired memory and reduced cognitive abilities, and, if the deprivation persists, mood swings and even hallucinations. [ncbi.nlm.nih.gov]
Lack of sleep can cause: Lack of energy Lower concentration levels and decision making abilities Headaches and dizziness Muscle aches Nausea Hand tremors Increased blood pressure Irritability and mood swings Memory lapses Hallucinations Additionally, [kidspot.com.au]
They may feel angry and impulsive, have mood swings, feel sad or depressed, or lack motivation. They also may have problems paying attention, and they may get lower grades and feel stressed. [nhlbi.nih.gov]
- Emotional Outbursts
Does your child have emotional outbursts? As parents, we all know what it feels like to be grumpy, contrary, and “not at our best” from lack of sleep. If our kids often feel this way, we owe it to them to find solutions to this problem. [drgreene.com]
- Chronic Anxiety
“I had extreme chronic anxiety, I was super emotional and impulsive, I couldn’t manage my appetite or keep a good workout regimen,” he said. “All the metrics people measure their success by ... I was suffering in all of them." [abcnews.go.com]
Neurologic
- Irritability
Irritability and loss of motivation are common outcomes of sleep deprivation. We look at each below. Irritability Sleep deprivation doesn’t just affect you. [optalert.com]
Marine Corps were offered mental health evaluation for sleep disturbance and symptoms of blunted affect, low mood, poor concentration, inability to focus, irritability, and drowsiness. All three patients reported insomnia as their primary complaint. [ncbi.nlm.nih.gov]
“It is common for managers and colleagues to look at a lack of focus or motivation, irritability, and bad decision making as being caused by poor training, organizational politics or the work environment. [hult.edu]
Symptoms include: Moodiness and irritability Temper tantrums The tendency to emotionally ‘explode’ at the slightest provocation Over-activity and hyperactive behaviour Daytime naps Grogginess when they wake up in the morning Reluctance to get out of bed [web.archive.org]
- Stroke
Anxiety Drowsiness, leading to drowsy driving Forgetfulness Distractibility Decreased performance and alertness Memory and cognitive impairment Stressed relationships Occupational injury Automobile injury Long-term: High blood pressure Heart attack Stroke [pamf.org]
Abstract Sleep deprivation is a major source of morbidity with widespread health effects, including increased risk of hypertension, diabetes, obesity, heart attack, and stroke. [ncbi.nlm.nih.gov]
A stroke worsened by sleep deprivation even caused the death of a Chinese man after binge-watching soccer for 48 hours. So close that laptop and get some shut-eye. [motherboard.vice.com]
- Confusion
RESULTS: Neurological deterioration as defined as a decrease in Glasgow Coma Scale score of 2 or more, an increase in National Institute of Health Stroke Scale score by 4 or more, or a change in Confusion Assessment Method score for use in intensive care [ncbi.nlm.nih.gov]
He also became upset, confused and paranoid. He hallucinated - at first, simple patterns like cobwebs on people's faces, or insects which were really specks of paint on the table. But soon, they became more intense, like waking dreams. [world-of-lucid-dreaming.com]
Effects include boredom, irritability, difficulty in concentrating, confusion, and inaccurate perception of sensory stimuli. [medical-dictionary.thefreedictionary.com]
- Cognitive Impairment
In this context, scientists have developed new experimental paradigms to artificially induce transient cognitive impairments in healthy volunteers akin to those observed in Alzheimer's disease, i.e. the Cognitive Challenge Models. [ncbi.nlm.nih.gov]
Short-term: Anxiety Drowsiness, leading to drowsy driving Forgetfulness Distractibility Decreased performance and alertness Memory and cognitive impairment Stressed relationships Occupational injury Automobile injury Long-term: High blood pressure Heart [pamf.org]
- Headache
After just one night of skimping on sleep, you'll experience changes in mood, headache, and hormone imbalances. One week of sleeping fewer than six hours a night can result in changes to more than 700 genes. [mindbodygreen.com]
Often, headaches and tension are found to increase after poor sleep; occasionally this may be accompanied by feelings of dizziness and light-headedness. It is recommended that you consult your doctor if you experience symptoms such as this. [sleepio.com]
That’s why people who are sleep deprived are susceptible to headaches, and part of why those who have stayed awake for 24 hours perform similarly to those with a blood alcohol content of 0.1 percent on many mental and physical tasks, he noted. [abcnews.go.com]
[…] can cause myriad symptoms: aching muscles, blurred vision, depression, color blindness, drowsiness, loss of concentration, weak immune system, dizziness, dark circles of the eyes, fainting, confusion, hallucinations, symptoms of drunkenness, tremors, headaches [world-of-lucid-dreaming.com]
Workup
We think that this is only possible if an extensive diagnostic workup is performed at the time of the first symptom, back pain. [jamanetwork.com]
Serum
- Hypoglycemia
OBJECTIVE: To ascertain whether hypoglycemia in association with sleep deprivation causes greater cognitive dysfunction than hypoglycemia alone and protracts cognitive recovery after normoglycemia is restored. [ncbi.nlm.nih.gov]
J Clin Endocrinol Metab 95 : 2963 – 2968 6. 2007 Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia. [doi.org]
Another commonly found condition in fibromyalgia which has nervous related symptoms is reactive hypoglycemia. [web.archive.org]
Treatment
Sleep deprivation treatment, its immediate but short-lived beneficial effect, may have a role in the treatment of the ultra-short depressions encountered in very rapid cycling. [ncbi.nlm.nih.gov]
Prognosis
Intramedullary metastases are associated with a poor prognosis. Up to two-thirds of patients die within six months of diagnosis 2. [radiopaedia.org]
A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 2005;30(19):2186-91. [ Links ] 15. Tokuhashi Y, Ajiro Y, Umezawa N. [scielo.br]
Patients with only one segment involved (C/T/L/Conus medullaris) had an apparently better prognosis than those with two-to-four involved segments (median OS: 7.0 vs 3.0 months) (P<0.01). [dovepress.com]
Etiology
Model systems of psychosis, such as schizotypy or sleep deprivation, are valuable in informing our understanding of the etiology of the disorder and aiding the development of new treatments. [ncbi.nlm.nih.gov]
Epidemiology
Epidemiologic studies, mainly of nurses, have revealed an association between sustained night work and a 50-100% higher incidence of breast cancer. [ncbi.nlm.nih.gov]
Numerous epidemiological studies also have revealed that adults who usually slept less than five hours per night have a greatly increased risk of having or developing diabetes. [web.archive.org]
Pathophysiology
The findings suggest that the use of biological tests to study affective syndromes occurring in Klinefelter patients might yield clues regarding the existence of pathophysiological common denominators of primary and Klinefelter-associated affective disorders [ncbi.nlm.nih.gov]
Greene Reviews | 08 November 2018 This Review describes the effects of short sleep duration on cardiovascular health and diseases, and the authors discuss the main pathophysiological mechanisms involved, taking into account both experimental data and [nature.com]
Pathophysiology The etiology and pathophysiology of chronic insomnia are unknown. [doi.org]
Prevention
This case demonstrates an interaction between antidepressant medication and partial sleep deprivation in the prevention of depressive mood cycles. [ncbi.nlm.nih.gov]
The results suggest that SD and nicotine may delay wound healing and that Se supplementation may accelerate wound healing by preventing nicotine-induced oxidative stress and lipid peroxidation. [doi.org]