A temporal relationship between drug intake, clinical presentation/recurrence, and temporally related resolution of lesions after drug withdrawal is described. [cancertm.com]

Eosinophils were present in 41.1% of the biopsies. In 47.9% of the cases, the infiltration extended as far as the deep dermal layer and 63% presented exocytosis. [scielo.br]

[…] atypical pyoderma gangrenosum when that condition presents on the hands. [thedoctorsdoctor.com]

We present a patient with a bullous presentation of Sweet syndrome who developed an aseptic splenic abscess. [ncbi.nlm.nih.gov]

• Fever

  Sweet's syndrome (Acute febrile neutrophilic dermatosis) is a rare skin disorder characrerized by fever, neutrophilic leucocytosis, and erythematous skin nodules. Wolff K, Goldsmith LA, Katz SI, et al: Sweet's Syndrome. [medical-dictionary.thefreedictionary.com]

  Major criteria Abrupt onset of tender or painful red or purplish plaques or nodules Biopsy shows inflammation that is composed mainly of neutrophils without vasculitis Minor criteria Preceding fever or infection Accompanying fever, painful joints, conjunctivitis [dermnetnz.org]

  Larger series of patients showed that fever and neutrophilia are not consistently present. [en.wikipedia.org]

• Pain

  Sweet, contemporary Brit. physician] A febrile illness with raised painful plaques on the limbs, face, and neck; neutrophilic leukocytosis; and dense neutrophilic infiltrates in the skin lesions. [medical-dictionary.thefreedictionary.com]

  It is characterised by deep, painful nodules and plaques. Skin lesions may ulcerate and discharge oily material. These may develop on any area of skin. Systemic symptoms include fever, malaise, and joint pains. [dermnetnz.org]

  The bumps grow quickly in size, spreading into painful clusters up to an inch (2.5 centimeters) or so in diameter. When to see a doctor If you develop a painful, red rash that quickly grows in size, see your doctor for appropriate treatment. [mayoclinic.org]

  Abdominal pain was generalized, 6 by 10 in intensity on the pain scale, and dull in character. It was worsened by food intake and relieved by bowel movement. The abdominal pain was associated with fever, chills, nausea and vomiting. [jmedicalcasereports.com]

• Inflammation

  All had fever, elevated markers of systemic inflammation, and typical skin lesions. [ncbi.nlm.nih.gov]

  Renal imaging was normal and he underwent a kidney biopsy which showed non-specific findings i.e. some tubulointerstitial inflammation and glomerulosclerosis with mild features of thrombotic microangiopathy (TMA). [renalfellow.blogspot.com]

• Anemia

  Tolerance of anemia has to be evaluated preoperatively and should require transfusion. [accessanesthesiology.mhmedical.com]

  CONCLUSION: When caring for patients with Sweet syndrome, dermatologists should be aware of the potential association of leukopenia, anemia, thrombocytopenia, absence of arthralgia, and histiocytoid or subcutaneous histopathology with malignancy. [ncbi.nlm.nih.gov]

  Premalignant conditions that have been reported in association with pediatric Sweet syndrome include myelodysplastic syndrome, aplastic anemia, and Fanconi anemia. [cancertherapyadvisor.com]

• Malaise

  A 49-year-old man developed an acute exacerbation of bilateral panuveitis and optic disc edema together with symptoms of a papular rash on his forearms, fevers, malaise, and arthalgias. [ncbi.nlm.nih.gov]

  Eleven days after the second treatment with infliximab, the patient presented with myalgias, subfebrile temperatures, and general malaise. [ard.bmj.com]

  Systemic symptoms include fever, malaise, and joint pains. There is an association with myeloid dysplastic syndromes. Biopsy shows lobular infiltration of neutrophils in the subcutaneous fat without vasculitis. [dermnetnz.org]

  She had malaise and reported that she felt hot but had no known fever. No laboratory tests were ordered. [mdedge.com]

• Diarrhea

  A 63-year-old man with a history of Crohn's disease presented with one-week duration of abdominal pain, diarrhea and hematochezia. He also noticed eruption of painful skin rashes all over his body at the same time. [ncbi.nlm.nih.gov]

  Systemic side effects of PCV13 include chills, fever, headache, vomiting, fatigue, arthralgia, myalgias, decreased appetite, and diarrhea, whereas its cutaneous adverse reactions are local injection site reactions, Sweet's syndrome, and deep morphea. [medical-dictionary.thefreedictionary.com]

  The fever and diarrhea stopped after a few days and joint swelling decreased. She was discharged 2 weeks after the admission with a rather good general condition. [ijms.sums.ac.ir]

  Case Presentation A 63 year-old man with a history of Crohn's disease for the past thirty years and hyperlipidemia presented with one week of abdominal pain, diarrhea and hematochezia. [jmedicalcasereports.com]

• Abdominal Bloating

  She complained of sore throat, nonproductive cough, painless oral ulcers, hand swelling, Raynaud’s phenomenon, erythroderma, and abdominal bloating. She denied illicit or prescribed drug use, drug allergies, alcohol, or tobacco. [hindawi.com]

• Thrombosis

  After 24 h, computed tomography (CT) was arranged of the orbits, paranasal sinuses, and brain in order to exclude orbital cellulitis, subperiosteal abscess, cavernous sinus thrombosis, or mucormycosis. [nature.com]

  The histopathogenesis of Behcet's disease mainly includes: a) granuloma, vasculitis, elastosis b) thrombosis, granuloma, neutrophil infiltration c) neutrophil infiltration, thrombosis, vasculitis d) atypical lymphocytes, thrombosis, vasculitis 14. [scielo.br]

  An Echo-color Doppler of the right arm vessels was performed to exclude thrombosis. Blood and skin cultures at presentation were negative. A skin biopsy was performed. [omicsonline.org]

• Tachycardia

  Renal: renal failure Pulmonary: bronchospasm, pulmonary hemorrhage Interferon-alpha Constitutional: influenza-like symptoms (fever, chills, headache, arthralgia) Musculoskeletal: myalgias, fatal rhabdomyolysis Cardiovascular: hypotension, dysrhythmia, tachycardia [cancertherapyadvisor.com]

  Physical examination revealed an afebrile, normotensive female with tachycardia (pulse 114), cobblestone appearance and erythema of bilateral tonsils with slight exudate, and shotty cervical lymphadenopathy. Cardiac and chest exam were normal. [hindawi.com]

• Palpitations

  The following day in clinic, the patient complained of painful erythematous papules and plaques as well as intermittent discomfort over the left chest which worsened with deep inspiration, palpitations, and Raynaud’s phenomenon. [hindawi.com]

• Aphthous Stomatitis

  Finally, our patients did not have a family history or past evidence for aphthous stomatitis, arthritis, myalgias, serositis, or abdominal symptoms suggestive of a congenital autoinflammatory syndrome. [jamanetwork.com]

  Important diseases for the differential diagnosis are: 107 EAR (recurrent aphthous stomatitis) and aphthae, cyclic neutropenia, viral infections, herpes simplex infection, cytomegalovirus infection, ulcers caused by other sexually transmitted diseases [scielo.br]

• Arthritis

  Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study. N Engl J Med 2000 ; 343 : 1594 –602. Kraetsch HG, Antoni C, Kalden JR, Manger B. [ard.bmj.com]

  […] accompanied by pustules; it is more common in females; in males, it is associated with cancer including lymphoma, leukaemia, solid tumours and myeloproliferative disorders; it is also associated with ulcerative colitis, monoclonal gammopathies, rheumatoid arthritis [medical-dictionary.thefreedictionary.com]

  Arthritis tends to parallel skin lesions and usually affects the hands, wrists, ankles, or knees. [rheumaknowledgy.com]

  At the time of this presentation, her maintenance medications for rheumatoid arthritis included sulfasalazine and azathioprine; this regimen had been stable for 3 years. [nejm.org]

  Semin Arthritis Rheum 1988 ; 17 : 143 –55. 6 Nolla JM, Juanola X, Valverde J, Roig‐Escofet D, Pagerols X, Servitge O. Arthritis in acute febrile neutrophilic dermatosis (Sweet's syndrome). [rheumatology.oxfordjournals.org]

• Arthralgia

  Systemic features include fever (>38°C in >80% of patients), malaise, conjunctivitis, episcleritis, iridocyclitis, oral ulcers, proteinuria, arthralgias, myalgias, and arthritis. [rheumaknowledgy.com]

  Systemic side effects of PCV13 include chills, fever, headache, vomiting, fatigue, arthralgia, myalgias, decreased appetite, and diarrhea, whereas its cutaneous adverse reactions are local injection site reactions, Sweet's syndrome, and deep morphea. [medical-dictionary.thefreedictionary.com]

  It presents clinically with polymorphic skin lesions, fever, arthralgia, and peripheral leukocytosis. In general, it is associated with infections, malignancy and drugs. [ncbi.nlm.nih.gov]

• Osteoporosis

  […] by Carrie Johnson, originally published by the Arthritis and Osteoporosis Western Australia in the Autumn 2018 issue of Arthritis Today magazine Some of us are naturally more flexible than others, or hypermobile as the medical people describe it. [ehlers-danlos.com]

  Hypothalamic-pituitary-adrenal (HPA) axis: steroid withdrawal syndrome, Addisonian crisis Metabolic: hyperglycemia, increased appetite (weight gain), hypertension, congestive heart failure (CHF), hypokalemia, hypertriglyceridemia, Cushingoid changes, menstrual changes Bone: osteoporosis [cancertherapyadvisor.com]

• Papule

  An uncommon self-limited (5–12 weeks) condition characterised by single or multiple erythematous papules and plaques ± accompanied by pustules; it is more common in females; in males, it is associated with cancer including lymphoma, leukaemia, solid tumours [medical-dictionary.thefreedictionary.com]

  […] definition Acute disease characterized by dark-red and slowly growing painful papules and plaques particularly on the face and the extremities accompanied by high fever and neutrophilic leukocytosis in the blood. [dermis.net]

  Cutaneous — The cutaneous lesions of Sweet syndrome typically present as tender, edematous, and inflamed papules, plaques, and nodules ( picture 1A-B ). [mulicia.pixnet.net]

  Four months later he presented with fever, constitutional symptoms and skin rash in the form of reddish papules & nodules involving the trunk, neck & face. Lesions got progressively worse and coalesced to form plaques. [renalfellow.blogspot.com]

  Figure 2 Back showing erythematous macules, papules, and some nodules below the neck. A 38-year-old woman developed malaise, fever, chills, bilateral conjunctivitis, arthralgia, and a dry cough. [jaci-inpractice.org]

• Erythema

  […] pustules; it is more common in females; in males, it is associated with cancer including lymphoma, leukaemia, solid tumours and myeloproliferative disorders; it is also associated with ulcerative colitis, monoclonal gammopathies, rheumatoid arthritis, erythema [medical-dictionary.thefreedictionary.com]

  Desquamation of skin following febrile illness Desquamation secondary to acute systemic illness Drug-induced desquamation of skin Epidermal collarette Erythema elevatum diutinum Erythema fugax Erythema marginatum in acute rheumatic fever Erythema scarlatiniforme [icd9data.com]

  Usual clinical differential diagnosis includes erythema multiforme, drug eruption, and erythema nodosum. Histiocytoid Sweet syndrome is considered an uncommon histopathological variant of the disease. [ncbi.nlm.nih.gov]

  Differential Diagnosis Leukocytoclastic vasculitis Erythema nodusum Drug reaction Erythema multiforme Managements Drug of choice: Systemic glucocorticoids Second-line agents are dapsone, colchicine, or potassium iodide Xtra High Yield Point On the boards [medrx-education.com]

• Blister

  The histopathological findings of the left arm biopsy showed a subepidermal blister with dense infiltrating neutrophils within the blister that were superficial to the middle layer of the dermis. [ncbi.nlm.nih.gov]

  Small papules (bumps) or vesicles (blisters) Larger thickened or swollen plaques (flat patches) or nodules (lumps) Pseudovesicular appearance (almost blistered) Annular (ring-shaped) lesions Erosions and ulcers resembling atypical pyoderma gangrenosum [dermnetnz.org]

  (C) Blisters show a favourable development towards the healing after to begin Infliximab 5mg/kg. Figure 1. [academic.oup.com]

  A: Blisters and crusted ulcers In the tho racolumbar region. B: Blisters and crusted ulcers in the left arm. Figure 2 Clinical Image. Blisters in right upper extremity. [scielo.conicyt.cl]

• Skin Rash

  Case Presentations Case 1 A man, aged 48 years, with a history of myelodysplastic syndrome, post-decitabine chemotherapy was admitted with a fever, skin rash, and pancytopenia. [ncbi.nlm.nih.gov]

  Discussion Sweet's syndrome has been described for the 1 st time by Robert Sweet as a case of skin rash, neutrophilic infiltration and fever. [jahjournal.org]

  Four months later he presented with fever, constitutional symptoms and skin rash in the form of reddish papules & nodules involving the trunk, neck & face. Lesions got progressively worse and coalesced to form plaques. [renalfellow.blogspot.com]

• Skin Plaque

  Skin biopsy revealed a dense dermal infiltration of neutrophils, which is compatible with Sweet syndrome. The confused mentality, fever, and erythematous skin plaques resolved after the administration of systemic corticosteroids. [ekjm.org]

  The characteristic dermatologic features of this condition include painful erythematous skin plaques, fever, leukocytosis, and dermal infiltration of neutrophils at skin biopsy. [pubs.rsna.org]

  Sweet's syndrome (acute febrile neutrophilic dermatosis) is an infrequent skin disease characterized by sudden onset of fever, leucocytosis and erythematous plaques or nodules infiltrated by neutrophils. [spandidos-publications.com]

• Compulsive Behavior

  […] caused by autism compulsive behaviors and hyperactivity They get worse over time, leading to: seizures severe cognitive problems progressive loss of motor skills (walking, speaking, feeding, etc.) [kidshealth.org]

• Malar Rash

  rash ANA, anti-Sm/RNP, anti-dsDNA Neutrophilic dermatitis Prednisone Responsive to treatment Gollol-Raju et al., 2009 [4] Female 23 NA Malar rash (lupus nephritis previously) ANA Acute inflammatory cells with overlying keratin debris, abundant neutrophilic [hindawi.com]

• Headache

  Systemic side effects of PCV13 include chills, fever, headache, vomiting, fatigue, arthralgia, myalgias, decreased appetite, and diarrhea, whereas its cutaneous adverse reactions are local injection site reactions, Sweet's syndrome, and deep morphea. [medical-dictionary.thefreedictionary.com]

  Her course of disease was complicated by arthralgias, episcleritis, headaches, and erythema nodosum-like subcutaneous involvement. There was marked improvement with discontinuation of the inciting antibiotics and initiation of systemic steroids. [ncbi.nlm.nih.gov]

  Additional symptoms may include headache, arthralgia, conjunctivitis, and episcleritis. Febrile upper respiratory tract infection, tonsillitis, or influenza like illness often precede the appearance of skin lesions. [whonamedit.com]

• Irritability

  Radiology 84: 599-609, 1965 Correlation between colonoscopy and histopathology of the colon in diverticular disease and the irritable colon syndrome. [eurekamag.com]

  Ulnar nerve entrapment occurs when the ulnar nerve in the arm becomes compressed or irritated. The ulnar nerve is one of the three main nerves in your arm. [orthoinfo.aaos.org]

  If needed, your dental team can also adjust or replace irritating dentures or prescribe you medication for a fungal infection in your mouth. Some doctors may prescribe a course of counselling and low-dose anti-depressants. [dentalhealth.org]

  Other Conditions People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome might be more likely to also have some of the following conditions: Fibromyalgia Irritable Bowel Syndrome (IBS) Multiple chemical sensitivities Temporomandibular disorders [webmd.com]

  This leads to irritation and swelling of the nerve. The condition mainly affects adults. In rare cases, it is seen in children. [mountsinai.org]

• Dizziness

  Dizzy or lightheaded feeling. Drooling and not being able to swallow. Full-body redness and warmth, called flushing. [mayoclinic.org]

  If you have dizziness, your provider can advise other medicines. Outlook (Prognosis) If there is not much damage to the nerve, you should get better completely within a few weeks. [mountsinai.org]

  Case presentation A 72-year-old patient was admitted to the Internal Medicine Department referring syncopal episodes which were associated with dizziness, diaphoresis, nausea without vomiting, hypotension and temperature up to 39 °C. [cco.amegroups.com]

  The most commonly (15-25% of patients) reported were: Ecchymosis, dizziness, headache (grade 1 or 2), diarrhea and asthenia. Hematologic adverse effects (anemia and thrombocytopenia) are dose-dependent. [clinmedjournals.org]

  You have nausea, dizziness, sweating, a racing heart, or shortness of breath. References Dixit S, Chang CJ. Thorax and abdominal injuries. In: Madden CC, Putukian M, McCarty EC, Young CC, eds. Netter's Sports Medicine. 2nd ed. [ucsfhealth.org]

• Agitation

  […] osteonecrosis, hypocalcemia Gastrointestinal: peptic ulcer disease, bowel perforation, fatty liver changes, esophageal reflux, nausea, vomiting Ocular: cataracts, glaucoma, infections (especially Staphylococcal), refraction changes Psychiatric: psychosis, agitation [cancertherapyadvisor.com]

• Lethargy

  […] alopecia, stomatitis, porphyria cutanea tarda Hematologic: myelosuppression Dapsone Gastrointestinal: gastric irritation, anorexia, hepatitis, cholestatic jaundice, hypoalbuminemia, pancreatitis, Hematologic: hemolytic anemia, methemoglobinemia (headache, lethargy [cancertherapyadvisor.com]

Additionally, we discuss the typical presentation of the syndrome, the proper workup and treatment, and a common pitfall encountered in the diagnosis of Sweet syndrome. [ncbi.nlm.nih.gov]

Extensive workup did not find any evidence of an underlying solid tumor or lymphoproliferative disorder. The patient was given prednisone, 1 mg/kg/d, with dose reduction across several weeks. [jamanetwork.com]

• Neutrophilia

  […] monoclonal gammopathies, rheumatoid arthritis, erythema nodosum, Sjögren syndrome, lupus erythematosus, vaccinations and various infections Management Systemic steroids Sweet syndrome Febrile neutrophilic dermatosis A rare condition characterized by fever, neutrophilia [medical-dictionary.thefreedictionary.com]

  BACKGROUND: Sweet syndrome (SS) is an infrequent skin disease characterised by sudden onset of fever, leukocytosis, neutrophilia, and tender erythematous plaques infiltrated by neutrophils. [ncbi.nlm.nih.gov]

  Although patients with neutrophilia are most likely to be diagnosed with Sweet’s syndrome, so, too, may patients who are neutropenic post-cytotoxic chemotherapy. [bloodjournal.org]

  Our patient presented with systemic upset, fever, neutrophilia and typical cutaneous, and histological features of Sweet syndrome. Surprisingly, IVIG resulted in a prompt and dramatic response in fever and neutrophilia. [hindawi.com]

  Larger series of patients showed that fever and neutrophilia are not consistently present. [en.wikipedia.org]

• Thrombocytopenia

  anaemia or thrombocytopenia, and without arthralgia are more likely to have malignancy-associated SS. [ncbi.nlm.nih.gov]

  Conclusions Patients with older age, anaemia or thrombocytopenia, and without arthralgia are more likely to have malignancy‐associated SS. [onlinelibrary.wiley.com]

  Associated leukocytosis and thrombocytopenia had also improved at that time. [karger.com]

• Hypogammaglobulinemia

  […] and neurologist,His father was anAmerican and his mother a Frenchwoman Brown-Pearce ブラウン・ピアース Brown-Pearce carcinoma ブラウン・ピアース癌 Brudzinski ブルジンスキー Brudzinski's sign ブルジンスキー徴候 JósefBrudziñski （1874-1917） Polish pediatrician Bruton ブルトン、ブロトン Bruton-type hypogammaglobulinemia [jams.med.or.jp]

• HLA-Bw54

  They found that the frequency of HLA-Bw54 was significantly higher in patients with Sweet syndrome than in controls, while there was no significant difference in the incidence of HLA-Bw54 between patients with Behcet disease and controls. [omim.org]

  Some authors speculate that a genetic predisposition may determine geographical variations in the incidence, since almost half of all reported ca ses have occurred in Japan, finding an association with human leukocyte antigen BW 54 (HLA-Bw54) in these [scielo.conicyt.cl]

  […] syndrome patients received G-CSF/GM-CSF, interferon-γ and all-trans retinoic acid (ATRA) and subsequently developed Sweet's syndrome.11 Although there is no consistent evidence of a genetic predisposition for Sweet's syndrome, a higher frequency of HLA-Bw54 [actasdermo.org]

• Leukocytosis

  Sweet, contemporary Brit. physician] A febrile illness with raised painful plaques on the limbs, face, and neck; neutrophilic leukocytosis; and dense neutrophilic infiltrates in the skin lesions. [medical-dictionary.thefreedictionary.com]

  […] definition Acute disease characterized by dark-red and slowly growing painful papules and plaques particularly on the face and the extremities accompanied by high fever and neutrophilic leukocytosis in the blood. [dermis.net]

  Both diagnoses are characterized by an acute onset of fever, leukocytosis, and tender, erythematous infiltrated plaques. [ncbi.nlm.nih.gov]

  A dictionary of medical eponyms Related people Robert Douglas Sweet A skin disease of unknown aetiology characterized by abrupt onset of fever, raised painful plaques on the limbs, face, and neck; neutrophilic leukocytosis; and dense dermal infiltration [whonamedit.com]

Surgical wound debridement was performed on the fingers and, because of immunosuppressive treatment (glucocorticoids, methotrexate, and azathioprine), systemic antibiotic treatment was started even in the absence of detectable systemic infection. [ard.bmj.com]

Severe ulcerative cases associated with malignancy persist, despite treatment. [dermnetnz.org]

The most common treatment for Sweet's syndrome is corticosteroid pills, such as prednisone. Signs and symptoms often disappear just a few days after treatment begins, but recurrence is common. [mayoclinic.org]

Treatment The treatment of choice in malignancy-associated Sweet’s syndrome is treatment of the underlying malignancy, which can result in complete resolution of the individual’s Sweet’s syndrome ( 2 ). [spandidos-publications.com]

Sweet syndrome (acute febrile neutrophilic dermatosis): Management and prognosis. UpToDate, Inc. 2013 Oct 8. [rarediseases.org]

In general, prognosis is good, but recurrences occur and second-line treatment may be needed. © 2014 The International Society of Dermatology. [ncbi.nlm.nih.gov]

Sweet syndrome (acute febrile neutrophilic dermatosis): Management and prognosis. http://www.uptodate.com/home. Accessed Sept. 24, 2015. Merola, JF. [mayoclinic.org]

Sweet syndrome or acute febrile neutrophilic dermatosis is a recurrent and rare skin disease caused by the release of cytokines, with diverse possible etiologic causes. [ncbi.nlm.nih.gov]

Etiology The pathogenesis of Sweet's syndrome may be multifactorial and still remains to be definitively established. Clinical and laboratory evidence suggests that cytokines have an etiologic role. [orpha.net]

We evaluated clinical, histopathological, and immunohistochemical findings of a case categorized as idiopathic histiocytoid Sweet syndrome in which clinical-epidemiological data raised the possibilities of Sweet syndrome, leprosy, and drug reaction. [ncbi.nlm.nih.gov]

Synonym: acute febrile neutrophilic dermatosis Epidemiology Manifests at any age, classic peaks at 30 to 60 years of age Often based on subtype Classic: 80% are women; 75–90% have a prior upper respiratory infection (URI); 30% recurrence Drug-induced: [unboundmedicine.com]

CONCLUSION: The clinical and epidemiological data found in our study are mostly similar to those found in the literature. [scielo.br]

Summary Epidemiology Several hundred cases of Sweet's syndrome have been published. Clinical description Sweet's syndrome presents in three clinical settings: classical (or idiopathic), malignancy-associated, and drug-induced. [orpha.net]

The observation of an association between Sweet syndrome and autoimmune diseases, such as pemphigus vulgaris, may ultimately lead to better understanding of the pathophysiology of this disease. [ncbi.nlm.nih.gov]

Etiology and Pathophysiology Pathogenesis is multifactorial. Theorized factors include hypersensitivity reactions, cytokine dysregulation, and infection. [unboundmedicine.com]

In this report, we will discuss pathophysiology, diagnosis and challenges in the treatment associated with malignancy-associated Sweet’s syndrome. [spandidos-publications.com]

[…] facilitating the early diagnosis and appropriate management of unique conditions such as necrotizing Sweet syndrome, anesthesiologists can not only play a more visible role as leaders in the emerging perioperative surgical home model, but they may also prevent [ncbi.nlm.nih.gov]

Taking good care of your skin by protecting it from the sun may also help to prevent it from returning. [healthline.com]